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- W1502015275 abstract "In cancer, therapies are targeted at 6 important pathways. In sepsis, there is ongoing controversy regarding the number and relative roles of pathways that are activated or repressed and which are important in the progression from health to death. Adding to complexity, there is interaction of pathways, there are differences in temporal pattern of up and down-regulation of pathways and there are different responses of pathways to therapies of sepsis. In this review, we define four key pathways of sepsis: (1) inflammation and immunity, (2) coagulation and fibrinolysis, (3) apoptosis, and (4) endocrine. Each of these pathways can impair endothelial function, a unifying aspect of the pathophysiology of sepsis. There are few studies of interactions of pathways except for the interacttion of inflammation/immunity with coagulation/fibrinolysis. Successful treatment of cancer requires that cancer therapies interrupt several key pathways of cancer. Accordingly, we suggest that successful treatment of sepsis will require therapies that interrupt several key pathways of sepsis. Perhaps the paucity of approved therapies for sepsis is related in part to the underevaluation of novel pathways, to lack of understanding of interactions of pathways and to lack of interruption of key pathways of sepsis." @default.
- W1502015275 created "2016-06-24" @default.
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- W1502015275 date "2011-01-01" @default.
- W1502015275 modified "2023-10-16" @default.
- W1502015275 title "Molecular Mechanisms of Sepsis" @default.
- W1502015275 cites W1209665789 @default.
- W1502015275 cites W140580067 @default.
- W1502015275 cites W1498421730 @default.
- W1502015275 cites W1501809547 @default.
- W1502015275 cites W1549568102 @default.
- W1502015275 cites W1565588031 @default.
- W1502015275 cites W1848882298 @default.
- W1502015275 cites W1902184421 @default.
- W1502015275 cites W1926790978 @default.
- W1502015275 cites W1963690783 @default.
- W1502015275 cites W1964091764 @default.
- W1502015275 cites W1965599951 @default.
- W1502015275 cites W1965751405 @default.
- W1502015275 cites W1966050446 @default.
- W1502015275 cites W1966608261 @default.
- W1502015275 cites W1967968285 @default.
- W1502015275 cites W1969468610 @default.
- W1502015275 cites W1970055715 @default.
- W1502015275 cites W1970943114 @default.
- W1502015275 cites W1972757665 @default.
- W1502015275 cites W1975500513 @default.
- W1502015275 cites W1976111574 @default.
- W1502015275 cites W1976320059 @default.
- W1502015275 cites W1976771389 @default.
- W1502015275 cites W1977131844 @default.
- W1502015275 cites W1984155824 @default.
- W1502015275 cites W1986206888 @default.
- W1502015275 cites W1989880837 @default.
- W1502015275 cites W1990089954 @default.
- W1502015275 cites W1993731501 @default.
- W1502015275 cites W1995684114 @default.
- W1502015275 cites W1995727086 @default.
- W1502015275 cites W1997928223 @default.
- W1502015275 cites W2001564526 @default.
- W1502015275 cites W2002311045 @default.
- W1502015275 cites W2003843045 @default.
- W1502015275 cites W2004641904 @default.
- W1502015275 cites W2010077858 @default.
- W1502015275 cites W2014302720 @default.
- W1502015275 cites W2015186816 @default.
- W1502015275 cites W2015339876 @default.
- W1502015275 cites W2019467923 @default.
- W1502015275 cites W2020222089 @default.
- W1502015275 cites W2020668766 @default.
- W1502015275 cites W2023911475 @default.
- W1502015275 cites W2027699993 @default.
- W1502015275 cites W2029039230 @default.
- W1502015275 cites W2029534671 @default.
- W1502015275 cites W2030605887 @default.
- W1502015275 cites W2032636734 @default.
- W1502015275 cites W2033200706 @default.
- W1502015275 cites W2033320490 @default.
- W1502015275 cites W2033817405 @default.
- W1502015275 cites W2037419271 @default.
- W1502015275 cites W2038218836 @default.
- W1502015275 cites W2040941329 @default.
- W1502015275 cites W2043255305 @default.
- W1502015275 cites W2043337264 @default.
- W1502015275 cites W2043765645 @default.
- W1502015275 cites W2044091607 @default.
- W1502015275 cites W2050076148 @default.
- W1502015275 cites W2050147761 @default.
- W1502015275 cites W2050940395 @default.
- W1502015275 cites W2056554475 @default.
- W1502015275 cites W2057465413 @default.
- W1502015275 cites W2057971800 @default.
- W1502015275 cites W2059156857 @default.
- W1502015275 cites W2059217150 @default.
- W1502015275 cites W2061402985 @default.
- W1502015275 cites W2062054105 @default.
- W1502015275 cites W2062922777 @default.
- W1502015275 cites W2064050260 @default.
- W1502015275 cites W2064718903 @default.
- W1502015275 cites W2066362538 @default.
- W1502015275 cites W2066611787 @default.
- W1502015275 cites W2067263136 @default.
- W1502015275 cites W2069407758 @default.
- W1502015275 cites W2070743921 @default.
- W1502015275 cites W2071591718 @default.
- W1502015275 cites W2071693928 @default.
- W1502015275 cites W2071734249 @default.
- W1502015275 cites W2072439886 @default.
- W1502015275 cites W2074044112 @default.
- W1502015275 cites W2074470366 @default.
- W1502015275 cites W2075631718 @default.
- W1502015275 cites W2076080662 @default.
- W1502015275 cites W2076502916 @default.
- W1502015275 cites W2077367122 @default.