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- W1502027962 abstract "Case report presentation:A 78 year-old lady was diagnosed with a conjonctival melanoma in 2010. She was treated with surgical resection, subsequent palliative radiotherapy and a second surgery at recurrence in December 2012. After trials on Lambrozilumab and Vemurafenib which caused deleterious side effects, she was treated with Dabrafenib, a BRAF inhibitor that revolutionned the treatment of melanoma in the last few years. During the treatment, she developped an acute motor weakness without bulbar or autonomic findings. The complete work-up including a lumbar puncture, brain and spine MRI and EMG testing were consistent with a primary demyelinating diffuse polyneuropathy. She improved after IVIG infusions, but relapsed after re-exposure to Dabrafenib. The complexity of this case relates to the fact that our patient was exposed to 3 different immunotherapies in a 6 months interval. The novelty of those drugs makes this case very challenging. It is the first case to our knowlegde of GBS triggered by Dabrafenib. The extensive work-up, the process leading to this diagnosis and the response to treatment will be detailed on the poster. Disclosure: Dr. Maurice has nothing to disclose. Dr. Marcus has nothing to disclose. Dr. Mason has received personal compensation for activities with Roche Diagnostics Corporation." @default.
- W1502027962 created "2016-06-24" @default.
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- W1502027962 date "2015-04-06" @default.
- W1502027962 modified "2023-09-27" @default.
- W1502027962 title "Guillain-Barre Syndrome after Treatment with Dabrafenib for Metastatic Recurrent Melaloma. (P4.232)" @default.
- W1502027962 hasPublicationYear "2015" @default.
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