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• W1502084555 abstract "Context: After five decades of Hepatitis B Virus (HBV) vaccine discovery, HBV is still a major public health problem. Due to the high genetic diversity of HBV and selective pressure of the host immune system, intra-host evolution of this virus in different clinical manifestations is a hot topic of research. HBV infection causes a range of clinical manifestations from acute to chronic infection, cirrhosis and hepatocellular carcinoma. Among all forms of HBV infection manifestations, fulminant hepatitis B infection possesses the highest fatality rate. Almost 1% of the acutely infected patients develop fulminant hepatitis B, in which the mortality rate is around 70%. Evidence Acquisition: All published papers deposited in Genbank, on the topic of fulminant hepatitis were reviewed and their virological aspects were investigated. In this review, we highlight the genomic diversity of HBV reported from patients with fulminant HBV infection. Results: The most commonly detected diversities affect regulatory motifs of HBV in the core and S region, indicating that these alterations may convert the virus to an aggressive strain. Moreover, mutations at T-cell and B-cell epitopes located in pre-S1 and pre-S2 proteins may lead to an immune evasion of the virus, likely favoring a more severe clinical course of infection. Furthermore, point and frame shift mutations in the core region increase the viral replication of HBV and help virus to evade from immune system and guarantee its persistence. Conclusions: Fulminant hepatitis B is associated with distinct mutational patterns of HBV, underlining that genomic diversity of the virus is an important factor determining its pathogenicity." @default.
• W1502084555 created "2016-06-24" @default.
• W1502084555 creator A5008139614 @default.
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• W1502084555 creator A5074064604 @default.
• W1502084555 creator A5074592383 @default.
• W1502084555 creator A5083825910 @default.
• W1502084555 date "2015-06-23" @default.
• W1502084555 modified "2023-10-17" @default.
• W1502084555 title "Genomic Diversity of Hepatitis B Virus Infection Associated With Fulminant Hepatitis B Development" @default.
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• W1502084555 doi "https://doi.org/10.5812/hepatmon.29477v2" @default.
• W1502084555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4533131" @default.
• W1502084555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26288637" @default.
• W1502084555 hasPublicationYear "2015" @default.
• W1502084555 type Work @default.
• W1502084555 sameAs 1502084555 @default.

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