Matches in SemOpenAlex for { <https://semopenalex.org/work/W1502089611> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1502089611 endingPage "179" @default.
- W1502089611 startingPage "175" @default.
- W1502089611 abstract "Abstract A major feature of human immunodeficiency virus (HIV) infection is disordered B-cell function, which paradoxically includes both pathologic overactivity (elevated serum antibodies, lymphadenopathy, and increased risk for lymphoma) and underactivity (impaired antibody immunity, particularly to bacterial polysaccharide antigens). B-cell immune dysfunction contributes significantly to HIV-related morbidity and also represents an obstacle to eventual definitive treatment by anti-HIV immunization. Our laboratory has recently identified in normal B-cell populations certain VH gene subfamilies with a developmentally regulated pattern of utilization. In particular, B cells bearing rearranged VH3L were rare in the germinal center but uniformly abundant in the blood and lymphoid mantle zone. We used this index gene subfamily as a clonal criterion for the pattern of B-cell development in lymphocytes of HIV-positive individuals. In a series of 19 HIV- positive subjects, a striking deficit of VH3L B cells was observed; in contrast, none of the 16 normal subjects showed this abnormality. Other VH subfamilies (VH1N, VH4/6, and VH5N) were unaffected in the HIV- positive patients. This VH3L clonal deficit and other recent phenotype and histopathologic findings suggest that the general B-cell dysfunction in HIV is due to a discreet maturational arrest at the germinal center stage." @default.
- W1502089611 created "2016-06-24" @default.
- W1502089611 creator A5007336183 @default.
- W1502089611 creator A5015745811 @default.
- W1502089611 creator A5031406053 @default.
- W1502089611 creator A5055490152 @default.
- W1502089611 creator A5090553690 @default.
- W1502089611 date "1991-07-01" @default.
- W1502089611 modified "2023-10-18" @default.
- W1502089611 title "A VH clonal deficit in human immunodeficiency virus-positive individuals reflects a B-cell maturational arrest [published erratum appears in Blood 1991 Oct 1;78(7):1899]" @default.
- W1502089611 cites W114797269 @default.
- W1502089611 cites W127278887 @default.
- W1502089611 cites W1515033630 @default.
- W1502089611 cites W188283621 @default.
- W1502089611 cites W1986432875 @default.
- W1502089611 cites W2000159884 @default.
- W1502089611 cites W2003452167 @default.
- W1502089611 cites W2018224585 @default.
- W1502089611 cites W2046872863 @default.
- W1502089611 cites W2068360506 @default.
- W1502089611 cites W2085587195 @default.
- W1502089611 cites W2088698018 @default.
- W1502089611 cites W2093044736 @default.
- W1502089611 cites W2114139304 @default.
- W1502089611 cites W2118588327 @default.
- W1502089611 cites W2119031927 @default.
- W1502089611 cites W2119063189 @default.
- W1502089611 cites W2119101345 @default.
- W1502089611 cites W2159669315 @default.
- W1502089611 cites W2172021909 @default.
- W1502089611 cites W2270251219 @default.
- W1502089611 cites W2416683529 @default.
- W1502089611 cites W2435383221 @default.
- W1502089611 cites W92258932 @default.
- W1502089611 doi "https://doi.org/10.1182/blood.v78.1.175.175" @default.
- W1502089611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2070051" @default.
- W1502089611 hasPublicationYear "1991" @default.
- W1502089611 type Work @default.
- W1502089611 sameAs 1502089611 @default.
- W1502089611 citedByCount "72" @default.
- W1502089611 countsByYear W15020896112012 @default.
- W1502089611 countsByYear W15020896112013 @default.
- W1502089611 countsByYear W15020896112014 @default.
- W1502089611 countsByYear W15020896112016 @default.
- W1502089611 crossrefType "journal-article" @default.
- W1502089611 hasAuthorship W1502089611A5007336183 @default.
- W1502089611 hasAuthorship W1502089611A5015745811 @default.
- W1502089611 hasAuthorship W1502089611A5031406053 @default.
- W1502089611 hasAuthorship W1502089611A5055490152 @default.
- W1502089611 hasAuthorship W1502089611A5090553690 @default.
- W1502089611 hasBestOaLocation W15020896111 @default.
- W1502089611 hasConcept C104317684 @default.
- W1502089611 hasConcept C127716648 @default.
- W1502089611 hasConcept C159047783 @default.
- W1502089611 hasConcept C159654299 @default.
- W1502089611 hasConcept C181152851 @default.
- W1502089611 hasConcept C203014093 @default.
- W1502089611 hasConcept C2522874641 @default.
- W1502089611 hasConcept C2777607303 @default.
- W1502089611 hasConcept C2778453870 @default.
- W1502089611 hasConcept C54355233 @default.
- W1502089611 hasConcept C86803240 @default.
- W1502089611 hasConcept C8891405 @default.
- W1502089611 hasConcept C96926380 @default.
- W1502089611 hasConceptScore W1502089611C104317684 @default.
- W1502089611 hasConceptScore W1502089611C127716648 @default.
- W1502089611 hasConceptScore W1502089611C159047783 @default.
- W1502089611 hasConceptScore W1502089611C159654299 @default.
- W1502089611 hasConceptScore W1502089611C181152851 @default.
- W1502089611 hasConceptScore W1502089611C203014093 @default.
- W1502089611 hasConceptScore W1502089611C2522874641 @default.
- W1502089611 hasConceptScore W1502089611C2777607303 @default.
- W1502089611 hasConceptScore W1502089611C2778453870 @default.
- W1502089611 hasConceptScore W1502089611C54355233 @default.
- W1502089611 hasConceptScore W1502089611C86803240 @default.
- W1502089611 hasConceptScore W1502089611C8891405 @default.
- W1502089611 hasConceptScore W1502089611C96926380 @default.
- W1502089611 hasIssue "1" @default.
- W1502089611 hasLocation W15020896111 @default.
- W1502089611 hasOpenAccess W1502089611 @default.
- W1502089611 hasPrimaryLocation W15020896111 @default.
- W1502089611 hasRelatedWork W1614256433 @default.
- W1502089611 hasRelatedWork W1998565949 @default.
- W1502089611 hasRelatedWork W2007314562 @default.
- W1502089611 hasRelatedWork W207300376 @default.
- W1502089611 hasRelatedWork W2136877952 @default.
- W1502089611 hasRelatedWork W2582697615 @default.
- W1502089611 hasRelatedWork W2731187888 @default.
- W1502089611 hasRelatedWork W2937775576 @default.
- W1502089611 hasRelatedWork W3010560328 @default.
- W1502089611 hasRelatedWork W4313356563 @default.
- W1502089611 hasVolume "78" @default.
- W1502089611 isParatext "false" @default.
- W1502089611 isRetracted "false" @default.
- W1502089611 magId "1502089611" @default.
- W1502089611 workType "article" @default.