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- W1502116783 abstract "Objective:To investigate the change in serum tissue inhibitor of metalloproteinase (TIMP)-1 level in patients with non-small cell lung cancer (NSCLC) before and after chemotherapy,and its correlation with efficacy of chemotherapy.Methods:Serum TIMP-1 levels were detected in 20 healthy subjects and 60 patients with advanced NSCLC before and after gemcitabine plus cisplatin chemotherapy by ELISA method. Its correlation with efficacy of chemotherapy was analyzed.Results:Serum TIMP-1 levels in NSCLC group was significantly higher than those in healthy volunteers(P0.01). Serum TIMP-1 levels were closely related to tumor size, but not related to the histological classification(adenocarcinoma and squamous carcinoma)and clinical stage(ⅢB and Ⅳ)(P0.05). Serum TIMP-1 levels in patients who had effective response on day 7 post-chemotherapy were significantly lower than those detected before chemotherapy (P0.01).There was no significant difference in serum TIMP-1 levels in non-responders before and after chemotherapy(P0.05). The serum TIMP-1 level in non-responders before chemotherapy were significantly higher than those in responders and healthy subjects(P0.01),while the difference between healthy volunteers and responders was not significant(P0.05).Conclusion:Serum TIMP-1 levels may be closely related to chemotherapy response and high levels of TIMP-1 indicates the NSCLC patients would had no response to gemcitabine and cisplatin (GP) regimen." @default.
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- W1502116783 date "2009-01-01" @default.
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- W1502116783 title "The value of serum TIMP-1 level for evaluation of the chemotherapeutic efficacy for patients with non-small cell lung carcinoma." @default.
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