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- W1502116797 abstract "Publisher Summary This chapter describes the identification of variant alleles of the human CYP1A1 gene. Individual differences in susceptibility to chemically induced cancers are ascribed partly to genetic differences in metabolic balance in the activation and detoxification of environmental procarcinogens. Human lung cancer requires exposure to the procarcinogens contained in cigarette smoke. CYP1A1 is expressed in the lung and metabolizes polycyclic aromatic hydrocarbons, such as benzo[ a ]pyrene, in cigarette smoke. If some of the genetic polymorphisms of the CYP1A1 gene correlate to the lung cancer incidence, this might be helpful in predicting the individual risk of cancer. The chapter proves that patients with susceptible genotypes of the CYP1A1 gene contracted carcinoma after smoking fewer cigarettes than those with other genotypes. These results were reconfirmed by a subsequent study in a different Japanese population. However, a lack of association between the CYP1A1 genotypes and lung cancer incidence has been reported in Caucasian populations. This discrepancy may be ascribed largely to the ethnic difference in the allelic frequency of the polymorphism." @default.
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- W1502116797 date "1996-01-01" @default.
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- W1502116797 title "[25] Identification of allelic variants of the humanCYP1A1 gene" @default.
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- W1502116797 doi "https://doi.org/10.1016/s0076-6879(96)72027-x" @default.
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