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- W1502165008 abstract "Abstract Hydrolysis of crab d(A-T)n and biosynthetic (dA)n·(dT)n by micrococcal nuclease was measured by titrimetric and spectrophotometric methods, and the ratio of dinucleotides to mononucleotides was determined at the midpoint and at the end point of the reaction. Hydrolysis of crab d(A-T)n shows similar kinetics when measured by both methods. With (dA)n·(dT)n the spectrophotometric method shows a lag period followed by a rapid increase in hyperchromicity. This is interpreted as evidence for the maintenance of ordered structure during early stages of the reaction. Kinetic measurements and product analysis lead to the following conclusions: (a) an exonucleolytic mechanism of action begins during early stages of the reaction; (b) it is more pronounced with (dA)n·(dT)n than with crab d(A-T)n; and (c) it is maximal at moderate ionic strength with (dA)n·(dT)n as substrate; (d) at low ionic strength (pH-stat), exonucleolysis occurs mainly on the dA strand of (dA)n·(dT)n." @default.
- W1502165008 created "2016-06-24" @default.
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- W1502165008 date "1969-07-01" @default.
- W1502165008 modified "2023-09-30" @default.
- W1502165008 title "Action of Micrococcal Nuclease on Polymers of Deoxyadenylic and Deoxythymidylic Acids" @default.
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- W1502165008 doi "https://doi.org/10.1016/s0021-9258(17)36423-2" @default.
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