Matches in SemOpenAlex for { <https://semopenalex.org/work/W150218645> ?p ?o ?g. }
- W150218645 abstract "Colorectal tumors with mutations on Wnt family members show an overexpression of several Notch target genes, suggesting a link between Wnt and Notch signaling pathways. In this work, we have demonstrated that there is a direct relation between Wnt and Notch pathways that it is responsible for the maintenance of the intestinal proliferative compartment and crucial for intestinal tumorigenesis. We have identified two different mechanisms through ?-catenin interacts with Notch to activate transcription: 1) ?-catenin activates Notch through the transcriptional activation of Notch ligand Jagged1. Jagged1 expression leads the binding to the Notch receptor, promoting its cleavage and activation. This mechanism occurs in human colorectal tumors, with nuclear ?-catenin, overexpressed Jagged1 and activated Notch. 2) ?-catenin and Notch bind simultaneously to a specific group of gene promoters. We observed that this group of genes is overexpressed in tumours with mutations in Wnt signaling. Moreover, ?-catenin and Notch physically interact in the nucleus of colorectal tumour cell lines. We have characterized a group of genes that are double target genes for ?-catenin and Notch; in other words, these genes require the activation of both Wnt and Notch signaling pathways. These genes are expressed in the intestinal undifferentiated compartment. The loss of any of these signalling pathways reduced stem cell marker expression, reinforcing the importance of the interaction between both signalling pathways. The study of conditional knockouts mice for Jagged1 indicated that Jagged1 is not required for maintaining the intestinal homeostasis. However, Jagged1 is crucial during the tumorigenic process. Our data opens a new possibility for colorectal treatment, using inhibitors of Notch ligand Jagged1, avoiding side effects in the intestinal normal tissue." @default.
- W150218645 created "2016-06-24" @default.
- W150218645 creator A5071797543 @default.
- W150218645 date "2011-05-13" @default.
- W150218645 modified "2023-09-23" @default.
- W150218645 title "WNT and NOTCH: Joining Efforts to Maintain the Intestinal Homeostasis" @default.
- W150218645 cites W114951656 @default.
- W150218645 cites W1507944948 @default.
- W150218645 cites W1508234976 @default.
- W150218645 cites W1511545125 @default.
- W150218645 cites W1560909626 @default.
- W150218645 cites W1564357553 @default.
- W150218645 cites W1568038787 @default.
- W150218645 cites W1577788507 @default.
- W150218645 cites W1586129343 @default.
- W150218645 cites W1631692643 @default.
- W150218645 cites W1660631781 @default.
- W150218645 cites W1668580308 @default.
- W150218645 cites W1768274470 @default.
- W150218645 cites W1846418786 @default.
- W150218645 cites W1955427151 @default.
- W150218645 cites W1963819880 @default.
- W150218645 cites W1964720708 @default.
- W150218645 cites W1965157206 @default.
- W150218645 cites W1966828612 @default.
- W150218645 cites W1967528766 @default.
- W150218645 cites W1967589170 @default.
- W150218645 cites W1967802833 @default.
- W150218645 cites W1967949450 @default.
- W150218645 cites W1968226123 @default.
- W150218645 cites W1969335165 @default.
- W150218645 cites W1969717239 @default.
- W150218645 cites W1971388047 @default.
- W150218645 cites W1972168412 @default.
- W150218645 cites W1973167499 @default.
- W150218645 cites W1973422437 @default.
- W150218645 cites W1974246469 @default.
- W150218645 cites W1975734011 @default.
- W150218645 cites W1975853332 @default.
- W150218645 cites W1975993620 @default.
- W150218645 cites W1976992342 @default.
- W150218645 cites W1977661665 @default.
- W150218645 cites W1978124642 @default.
- W150218645 cites W1980415581 @default.
- W150218645 cites W1983014406 @default.
- W150218645 cites W1983804855 @default.
- W150218645 cites W1985436261 @default.
- W150218645 cites W1987662957 @default.
- W150218645 cites W1989215255 @default.
- W150218645 cites W1989415637 @default.
- W150218645 cites W1989970624 @default.
- W150218645 cites W1990442683 @default.
- W150218645 cites W1990879144 @default.
- W150218645 cites W1991350273 @default.
- W150218645 cites W1992372073 @default.
- W150218645 cites W1992863892 @default.
- W150218645 cites W1993230767 @default.
- W150218645 cites W1995996847 @default.
- W150218645 cites W1996131261 @default.
- W150218645 cites W1996302902 @default.
- W150218645 cites W1996763333 @default.
- W150218645 cites W1996984755 @default.
- W150218645 cites W2000130011 @default.
- W150218645 cites W2000589976 @default.
- W150218645 cites W2002669389 @default.
- W150218645 cites W2003927439 @default.
- W150218645 cites W2004325660 @default.
- W150218645 cites W2006239354 @default.
- W150218645 cites W2006718453 @default.
- W150218645 cites W2007364588 @default.
- W150218645 cites W2007731740 @default.
- W150218645 cites W2008221746 @default.
- W150218645 cites W2010828866 @default.
- W150218645 cites W2011190652 @default.
- W150218645 cites W2011842366 @default.
- W150218645 cites W2011910303 @default.
- W150218645 cites W2013306879 @default.
- W150218645 cites W2013351311 @default.
- W150218645 cites W2013444425 @default.
- W150218645 cites W2013732926 @default.
- W150218645 cites W2014535758 @default.
- W150218645 cites W2016099927 @default.
- W150218645 cites W2016633058 @default.
- W150218645 cites W2017104522 @default.
- W150218645 cites W2017862163 @default.
- W150218645 cites W2018348035 @default.
- W150218645 cites W2018537679 @default.
- W150218645 cites W2018602900 @default.
- W150218645 cites W2018620221 @default.
- W150218645 cites W2020036904 @default.
- W150218645 cites W2023002592 @default.
- W150218645 cites W2024121049 @default.
- W150218645 cites W2025453970 @default.
- W150218645 cites W2027768926 @default.
- W150218645 cites W2029042594 @default.
- W150218645 cites W2029083736 @default.
- W150218645 cites W2029231546 @default.
- W150218645 cites W2029857102 @default.
- W150218645 cites W2031522329 @default.
- W150218645 cites W2032031347 @default.