FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1502195451> ?p ?o ?g. }

• W1502195451 endingPage "2711" @default.
• W1502195451 startingPage "2705" @default.
• W1502195451 abstract "Abstract An improved method for the isolation of rat pancreatic islets possessing adenylate cyclase responsive to various hormones and agents is described. The key step in this method, which yielded up to 500 islets per pancreas, involved pretreatment of rats with pilocarpine. This allowed depletion of zymogens from the exocrine pancreatic tissue and thus minimized the destruction of islet membranal structure which could otherwise occur during the collagenase digestion of the tissue. The adenylate cyclase activity in the islet homogenates was assayed in the presence of a variety of hormones and other agents. With the exception of some insulinogenic metabolites, such as glucose, arginine, and leucine, all hormones previously shown by others to stimulate insulin secretion were found to augment the synthesis of adenosine 3',5'-monophosphate (cyclic AMP) by islet adenylate cyclase. These agents include glucagon, adrenocorticotropic hormone, secretin, pancreozymin, various prostaglandins, and β-adrenergic agents. Acetylcholine, ethanol, EGTA, GTP, and GDP, also stimulated cyclic AMP production, but their insulinogenic action has not been clearly shown. Of the two hypoglycemic drugs studied, tolbutamide was found to stimulate the cyclase activity whereas phenformin was without effect. Insulin inhibited the islet adenylate cyclase activity, suggesting a possible feedback mechanism involved in regulating insulin secretion. NaF was most effective in activating the islet adenylate cyclase. None of the above-mentioned agents had any effect on the islet phosphodiesterase activity. Based upon the above observations, it is suggested that cyclic AMP may mediate the action of certain insulin-releasing agents whereas some other agents exert their insulinogenic action via mechanisms in which cyclic AMP may not be involved." @default.
• W1502195451 created "2016-06-24" @default.
• W1502195451 creator A5006125197 @default.
• W1502195451 creator A5060627911 @default.
• W1502195451 creator A5088925852 @default.
• W1502195451 date "1973-04-01" @default.
• W1502195451 modified "2023-10-13" @default.
• W1502195451 title "Adenylate Cyclase in Islets of Langerhans" @default.
• W1502195451 cites W1490796893 @default.
• W1502195451 cites W1517972603 @default.
• W1502195451 cites W1527858178 @default.
• W1502195451 cites W1528598569 @default.
• W1502195451 cites W1539796768 @default.
• W1502195451 cites W1544826192 @default.
• W1502195451 cites W1549058772 @default.
• W1502195451 cites W1571668265 @default.
• W1502195451 cites W1578024134 @default.
• W1502195451 cites W1775749144 @default.
• W1502195451 cites W1840645315 @default.
• W1502195451 cites W1863678882 @default.
• W1502195451 cites W1898548079 @default.
• W1502195451 cites W1968835696 @default.
• W1502195451 cites W1970680182 @default.
• W1502195451 cites W1975070600 @default.
• W1502195451 cites W1990675967 @default.
• W1502195451 cites W1995154265 @default.
• W1502195451 cites W1996583478 @default.
• W1502195451 cites W2007851330 @default.
• W1502195451 cites W2013525757 @default.
• W1502195451 cites W2016786791 @default.
• W1502195451 cites W2017052823 @default.
• W1502195451 cites W2027408573 @default.
• W1502195451 cites W2028285911 @default.
• W1502195451 cites W2033137631 @default.
• W1502195451 cites W2037027282 @default.
• W1502195451 cites W2038021560 @default.
• W1502195451 cites W2038489221 @default.
• W1502195451 cites W2047290083 @default.
• W1502195451 cites W2049960398 @default.
• W1502195451 cites W2053381734 @default.
• W1502195451 cites W2054406056 @default.
• W1502195451 cites W2061929605 @default.
• W1502195451 cites W2070661250 @default.
• W1502195451 cites W2070780599 @default.
• W1502195451 cites W2074556275 @default.
• W1502195451 cites W2079218217 @default.
• W1502195451 cites W2100869041 @default.
• W1502195451 cites W2102048187 @default.
• W1502195451 cites W2105742236 @default.
• W1502195451 cites W2121794771 @default.
• W1502195451 cites W2129579474 @default.
• W1502195451 cites W2142211920 @default.
• W1502195451 cites W2157865424 @default.
• W1502195451 cites W2165099278 @default.
• W1502195451 cites W2318923832 @default.
• W1502195451 cites W2325594416 @default.
• W1502195451 cites W4244826848 @default.
• W1502195451 doi "https://doi.org/10.1016/s0021-9258(19)44063-5" @default.
• W1502195451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4144542" @default.
• W1502195451 hasPublicationYear "1973" @default.
• W1502195451 type Work @default.
• W1502195451 sameAs 1502195451 @default.
• W1502195451 citedByCount "162" @default.
• W1502195451 countsByYear W15021954512013 @default.
• W1502195451 countsByYear W15021954512014 @default.
• W1502195451 countsByYear W15021954512017 @default.
• W1502195451 countsByYear W15021954512022 @default.
• W1502195451 countsByYear W15021954512023 @default.
• W1502195451 crossrefType "journal-article" @default.
• W1502195451 hasAuthorship W1502195451A5006125197 @default.
• W1502195451 hasAuthorship W1502195451A5060627911 @default.
• W1502195451 hasAuthorship W1502195451A5088925852 @default.
• W1502195451 hasBestOaLocation W15021954511 @default.
• W1502195451 hasConcept C126322002 @default.
• W1502195451 hasConcept C134018914 @default.
• W1502195451 hasConcept C165220095 @default.
• W1502195451 hasConcept C170493617 @default.
• W1502195451 hasConcept C180526460 @default.
• W1502195451 hasConcept C185592680 @default.
• W1502195451 hasConcept C2780069284 @default.
• W1502195451 hasConcept C55493867 @default.
• W1502195451 hasConcept C555293320 @default.
• W1502195451 hasConcept C71924100 @default.
• W1502195451 hasConcept C86803240 @default.
• W1502195451 hasConcept C95444343 @default.
• W1502195451 hasConceptScore W1502195451C126322002 @default.
• W1502195451 hasConceptScore W1502195451C134018914 @default.
• W1502195451 hasConceptScore W1502195451C165220095 @default.
• W1502195451 hasConceptScore W1502195451C170493617 @default.
• W1502195451 hasConceptScore W1502195451C180526460 @default.
• W1502195451 hasConceptScore W1502195451C185592680 @default.
• W1502195451 hasConceptScore W1502195451C2780069284 @default.
• W1502195451 hasConceptScore W1502195451C55493867 @default.
• W1502195451 hasConceptScore W1502195451C555293320 @default.
• W1502195451 hasConceptScore W1502195451C71924100 @default.
• W1502195451 hasConceptScore W1502195451C86803240 @default.
• W1502195451 hasConceptScore W1502195451C95444343 @default.
• W1502195451 hasIssue "8" @default.

• next