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- W1502202285 abstract "Abstract A 10-fold difference in activity of the liver enzyme, N1-methylnicotinamide oxidase, was found between mice of strains C57BL/6 and DBA/2. The Km value for the enzyme from DBA/2 mice with low activity was twice that of the enzyme from C57BL/6 mice. The activity difference segregated in F1, F2, and backcross generations as though it were genetically controlled by a single autosomal locus with alleles acting in an additive manner. The 2- to 4-fold higher activity in the adult male as compared to the adult female within each strain indicated that hormonal control of N1-methylnicotinamide oxidation was operating in addition to direct genetic control. Evidence from immature mice and from castrated and testosterone-treated animals supports the role of testosterone in increasing N1-methylnicotinamide oxidation." @default.
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- W1502202285 date "1967-03-01" @default.
- W1502202285 modified "2023-10-14" @default.
- W1502202285 title "Genetic and Androgenic Control of N1-Methylnicotinamide Oxidase Activity in Mice" @default.
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- W1502202285 doi "https://doi.org/10.1016/s0021-9258(18)96173-9" @default.
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