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- W1502299493 abstract "Group B Strep(GBS) infusions cause acute P-HTN in several animal models. This response includes increased pulmonary artery pressure (Ppa), and resistance (PVR), and decreased pulmonary flow; systemic flows are often decreased. We infused a bolus of PNEU in 2, <2-wk-old, acutely-operated, anesthetized lambs and found that P-HTN occurred. We then studied this effect in 2 unanesthetized, chronically-instrumented piglets, <1 mo. old. Infused bacteria were heat-killed, washed and resuspended in buffer. The pigs received 1 item/day at 3-4.5 × 109 particles/dose. Qualitatively similar severe P-HTN resulted from bolus infusions of all PNEU strains tested (P1, P14, and P23) also from Group E, Group G, and a nontypeable Group B Strep, Staph aureus, and zymosan. Agitation, cyanosis, systemic hypotension, bradycardia and seizures also occurred. Latex particles, similar size as bacteria, had no effect at this dose. A mild, transient rise in Ppa and PVR was noted after a double dose, suggesting that a quantity of particles alone doesn't produce the same P-HTN. Indomethacin blocked the P-HTN caused by PNEU. We conclude that P-HTN is a nonspecific host response that can be elicited by a variety of GM+ bacteria. Agent(s) that may trigger the response are not unique to GBS or endotoxin. Cyclooxygenase pathway products appear to mediate this P-HTN which may be clinically important in shock occurring with GM+ infections." @default.
- W1502299493 created "2016-06-24" @default.
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- W1502299493 date "1984-04-01" @default.
- W1502299493 modified "2023-09-27" @default.
- W1502299493 title "PULMONARY HYPERTENSION(P-HTN) FOLLOWING BOLUS INFUSIONS OF PNEUMOCOCCUS(PNEU), OTHER GRAM+(GM+) BACTERIA, AND ZYMOSAN" @default.
- W1502299493 doi "https://doi.org/10.1203/00006450-198404001-01168" @default.
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