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- W150243682 abstract "Chiral preparative chromatography has long been disregarded as a potential means of production of chiral compounds at industrial scale. However, with the development of scalable chromatographic technologies including continuous processes, preparative chiral stationary phases (CSPs), and process development methodologies, it has now emerged as one of the most time-efficient and cost-effective means of producing large volumes of enantiomerically pure compounds. In this chapter, all aspects of industrial chiral chromatography are covered. This includes its principles and its differences with analytical chromatography; modern preparative CSPs, and method development; the main preparative chromatography techniques including batch processes such as high performance liquid chromatography (HPLC) and superficial fluid chromatography (SFC), continuous processes such as simulated moving bed and Varicol as well as solvent recycling technologies; current large-scale process development methodologies; and the successful integration of chiral chromatography in a global chiral synthesis through various industrial examples." @default.
- W150243682 created "2016-06-24" @default.
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- W150243682 date "2012-01-01" @default.
- W150243682 modified "2023-10-17" @default.
- W150243682 title "9.17 Industrial Applications of Chiral Chromatography" @default.
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- W150243682 doi "https://doi.org/10.1016/b978-0-08-095167-6.00920-4" @default.
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