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- W1502472986 abstract "Abstract Preclinical Research S chisandrae C hinensis F ructus ( SCF ), the fruit of S chisandra chinensis ( T urcz.) B aill. (family S chisandraceae ) is traditionally used as a tonic and antidiabetic agent in A sia. In this study, SCF was investigated for its effects on sodium glucose cotransporters 1 and 2 ( SGLT 1 and 2) expressed in a COS ‐7 cell line for its specificity in inhibiting SGLT2 , which is a novel mechanism to screen for potential antidiabetic agents. Using a bioassay‐guided fractionation, we then tried to isolate and identify the active fraction(s)/component(s). The ethanol extract of SCF at a concentration of 1 mg/mL significantly inhibited 89% of SGLT1 and 73% of SGLT2 activities in a [ 14 C ]‐α‐methyl‐d‐glucopyranoside ([ 14 C ]‐ AMG ) uptake assay. Fractionation of the ethanol extract yielded nine fractions, of which F8 , at a concentration of 1 mg/mL, was specific in inhibiting SGLT 2 (42% inhibition, P < 0.001), without inhibiting SGLT 1. Using LC / MS ‐ MS , three compounds, deoxyschisandrin, schisandrin B (γ‐schisandrin) and schisandrin were identified in F8 and their amounts quantified. However, subsequent evaluation in the [ 14 C ]‐ AMG uptake assay showed that these three compounds failed to inhibit SGLT 2 activity indicating that the SGLT active component(s) from SCF have yet to be identified. Drug Dev Res 76 : 1–8, 2015" @default.
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- W1502472986 date "2014-11-18" @default.
- W1502472986 modified "2023-10-16" @default.
- W1502472986 title "Antidiabetic Effect of Schisandrae Chinensis Fructus Involves Inhibition of the Sodium Glucose Cotransporter" @default.
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- W1502472986 doi "https://doi.org/10.1002/ddr.21233" @default.
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