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- W1502555943 abstract "This chapter discusses survival surgery for coronary occlusion and reoxygenation in a rodent model. Development of animal models based on survival surgery allows the study of tissue remodeling in response to a specific insult. The importance of having a model that is clinically relevant underlies the attractiveness of the widely used coronary artery ligation model in the rat in which the left anterior descending artery (LAD) is temporarily occluded. The progression of heart failure in these rats is similar to the clinical syndrome of heart failure following anterior wall myocardial infarction. LAD occlusion results in acute myocardial ischemia with left ventricle (LV) dysfunction, decreased contractility, and elevated filling pressures. Reduction in blood pressure, cardiac output, and stroke volume suggest forward failure with LV dilatation and hypertrophy. This chapter describes a simplified approach to study the long-term effects of ischemia–reperfusion in the rat heart. The procedure to conduct such survival surgery with a degree of success and efficiency and different steps including preoperative anesthesia, endotracheal intubation, coronary occlusion and reperfusion, thoracotomy closure, postoperative monitoring, and harvesting of tissue are discussed." @default.
- W1502555943 created "2016-06-24" @default.
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- W1502555943 date "2004-01-01" @default.
- W1502555943 modified "2023-10-17" @default.
- W1502555943 title "Survival Surgery for Coronary Occlusion and Reoxygenation in a Rodent Model" @default.
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- W1502555943 doi "https://doi.org/10.1016/s0076-6879(04)81011-5" @default.
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