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- W1502587712 abstract "Abstract Rationale Many immune effector cells that are implicated in asthma express phosphodiesterase 4 (PDE4). Inhibition of PDE4 decreases eosinophil chemotaxis and tissue infiltration. Roflumilast is a novel, potent, selective PDE4 inhibitor in clinical development for the treatment of asthma and COPD. Methods Two separate, randomized, placebo-controlled studies assessed inhibition of early asthmatic response (EAR) and late asthmatic response (LAR) by Roflumilast in patients with mild allergic asthma. In the first study, designed as a pilot study (2-period crossover, N=13), patients received a single oral dose of 1000μg Roflumilast or placebo 1 h before allergen challenge. In the second study (3-period crossover, N=23), patients were treated for 7–10 days with oral Roflumilast 250μg, 500μg, or placebo once daily. Allergen challenge was performed on the last day of each treatment period. Results A single dose of 1000μg Roflumilast significantly inhibited maximal LAR by 62% ( P P P Conclusions Roflumilast significantly inhibited LAR in patients with allergic asthma. Eosinophils are the major effector cells in LAR, and the more pronounced inhibition of LAR by roflumilast supports the hypothesis that potent anti-inflammatory properties of Roflumilast may translate into clinical efficacy." @default.
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- W1502587712 date "2004-02-01" @default.
- W1502587712 modified "2023-09-25" @default.
- W1502587712 title "Inhibition of late asthmatic reaction in allergic asthma by the novel, selective PDE4 inhibitor Roflumilast*1" @default.
- W1502587712 doi "https://doi.org/10.1016/j.jaci.2004.01.251" @default.
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