Matches in SemOpenAlex for { <https://semopenalex.org/work/W150262505> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W150262505 endingPage "19" @default.
- W150262505 startingPage "3" @default.
- W150262505 abstract "Chitin, poly-β-(1→4) linked N-acetyl-D-glucosamine, is a highly hydrophobic material that is insoluble in water and most ordinary solvents. This property of chitin restricts its use to applications that do not require solubilization of the polymer. Several useful derivatives of chitin have been prepared that increase the hydrophilicity of the polymer. One of these derivatives is prepared by deacetylation of chitin's N-acetyl-glucosamine units in strong alkali. Deacetylated chitin is soluble in dilute acidic solutions and, in some cases, depending on the degree of deacetylation, in water. Although the maximally deacetylated material, chitosan, is not degraded by lysozyme, partially deacetylated chitin is a substrate for lysozyme digestion. Kinetic studies of the degradation reaction show that the hydrolysis of partially deacetylated chitin by lysozyme and a lysozyme-hapten conjugate follows typical Michaelis-Menten kinetics. Apparent K m values for the native and modified enzymes were 45 μg/ml and 40 μUg/ml, respectively. Dilute acidic solutions of partially deacetylated chitin were cast to form tough, flexible, water-insoluble films or crosslinked with glutaraldehyde to form hydrogels. Both of these fabrications were found to be lysozyme degradable. These data are discussed in relationship to the possible use of partially deacetylated chitin in bioerodible drug delivery systems." @default.
- W150262505 created "2016-06-24" @default.
- W150262505 creator A5002980568 @default.
- W150262505 creator A5025317199 @default.
- W150262505 creator A5028333565 @default.
- W150262505 date "1984-01-01" @default.
- W150262505 modified "2023-10-01" @default.
- W150262505 title "PARTIALLY DEACETYLATED CHITIN: ITS USE IN SELF-REGULATED DRUG DELIVERY SYSTEMS" @default.
- W150262505 cites W1535217499 @default.
- W150262505 cites W1561750927 @default.
- W150262505 cites W1775749144 @default.
- W150262505 cites W1828500240 @default.
- W150262505 cites W1891138220 @default.
- W150262505 cites W1971209096 @default.
- W150262505 cites W1996514181 @default.
- W150262505 cites W2002833331 @default.
- W150262505 cites W2016384087 @default.
- W150262505 cites W2082663346 @default.
- W150262505 cites W2088981438 @default.
- W150262505 cites W2092834380 @default.
- W150262505 cites W2118033980 @default.
- W150262505 cites W2165000962 @default.
- W150262505 cites W2503920477 @default.
- W150262505 doi "https://doi.org/10.1016/b978-0-12-780950-2.50007-1" @default.
- W150262505 hasPublicationYear "1984" @default.
- W150262505 type Work @default.
- W150262505 sameAs 150262505 @default.
- W150262505 citedByCount "18" @default.
- W150262505 countsByYear W1502625052014 @default.
- W150262505 crossrefType "book-chapter" @default.
- W150262505 hasAuthorship W150262505A5002980568 @default.
- W150262505 hasAuthorship W150262505A5025317199 @default.
- W150262505 hasAuthorship W150262505A5028333565 @default.
- W150262505 hasConcept C126348684 @default.
- W150262505 hasConcept C127413603 @default.
- W150262505 hasConcept C171250308 @default.
- W150262505 hasConcept C192562407 @default.
- W150262505 hasConcept C2779732960 @default.
- W150262505 hasConcept C2779820397 @default.
- W150262505 hasConcept C2780035454 @default.
- W150262505 hasConcept C2781088250 @default.
- W150262505 hasConcept C42360764 @default.
- W150262505 hasConcept C71924100 @default.
- W150262505 hasConcept C98274493 @default.
- W150262505 hasConceptScore W150262505C126348684 @default.
- W150262505 hasConceptScore W150262505C127413603 @default.
- W150262505 hasConceptScore W150262505C171250308 @default.
- W150262505 hasConceptScore W150262505C192562407 @default.
- W150262505 hasConceptScore W150262505C2779732960 @default.
- W150262505 hasConceptScore W150262505C2779820397 @default.
- W150262505 hasConceptScore W150262505C2780035454 @default.
- W150262505 hasConceptScore W150262505C2781088250 @default.
- W150262505 hasConceptScore W150262505C42360764 @default.
- W150262505 hasConceptScore W150262505C71924100 @default.
- W150262505 hasConceptScore W150262505C98274493 @default.
- W150262505 hasLocation W1502625051 @default.
- W150262505 hasOpenAccess W150262505 @default.
- W150262505 hasPrimaryLocation W1502625051 @default.
- W150262505 hasRelatedWork W2088595294 @default.
- W150262505 hasRelatedWork W2948758012 @default.
- W150262505 hasRelatedWork W2962821860 @default.
- W150262505 hasRelatedWork W3001914597 @default.
- W150262505 hasRelatedWork W3091612383 @default.
- W150262505 hasRelatedWork W3157244191 @default.
- W150262505 hasRelatedWork W4210645429 @default.
- W150262505 hasRelatedWork W4285148367 @default.
- W150262505 hasRelatedWork W4293192944 @default.
- W150262505 hasRelatedWork W2291752956 @default.
- W150262505 isParatext "false" @default.
- W150262505 isRetracted "false" @default.
- W150262505 magId "150262505" @default.
- W150262505 workType "book-chapter" @default.