FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1502632993> ?p ?o ?g. }

• W1502632993 endingPage "1460" @default.
• W1502632993 startingPage "1444" @default.
• W1502632993 abstract "BACKGROUND AND PURPOSE Cannabichromene (CBC) is a major non‐psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin‐1 (TRPA1). Both endocannabinoids and TRPA1 may modulate gastrointestinal motility. Here, we investigated the effect of CBC on mouse intestinal motility in physiological and pathological states. EXPERIMENTAL APPROACH Inflammation was induced in the mouse small intestine by croton oil. Endocannabinoid (anandamide and 2‐arachidonoyl glycerol), palmitoylethanolamide and oleoylethanolamide levels were measured by liquid chromatography‐mass spectrometry; TRPA1 and cannabinoid receptors were analysed by quantitative RT‐PCR; upper gastrointestinal transit, colonic propulsion and whole gut transit were evaluated in vivo ; contractility was evaluated in vitro by stimulating the isolated ileum, in an organ bath, with ACh or electrical field stimulation (EFS). KEY RESULTS Croton oil administration was associated with decreased levels of anandamide (but not 2‐arachidonoyl glycerol) and palmitoylethanolamide, up‐regulation of TRPA1 and CB 1 receptors and down‐regulation of CB 2 receptors. Ex vivo CBC did not change endocannabinoid levels, but it altered the mRNA expression of TRPA1 and cannabinoid receptors. In vivo , CBC did not affect motility in control mice, but normalized croton oil‐induced hypermotility. In vitro , CBC reduced preferentially EFS‐ versus ACh‐induced contractions. Both in vitro and in vivo , the inhibitory effect of CBC was not modified by cannabinoid or TRPA1 receptor antagonists. CONCLUSION AND IMPLICATIONS CBC selectively reduces inflammation‐induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1." @default.
• W1502632993 created "2016-06-24" @default.
• W1502632993 creator A5002541055 @default.
• W1502632993 creator A5007484138 @default.
• W1502632993 creator A5027741017 @default.
• W1502632993 creator A5043867481 @default.
• W1502632993 creator A5049123139 @default.
• W1502632993 creator A5051434178 @default.
• W1502632993 creator A5051892931 @default.
• W1502632993 creator A5056784492 @default.
• W1502632993 creator A5059461366 @default.
• W1502632993 creator A5086116359 @default.
• W1502632993 date "2012-05-17" @default.
• W1502632993 modified "2023-10-17" @default.
• W1502632993 title "Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice" @default.
• W1502632993 cites W139909318 @default.
• W1502632993 cites W1502864129 @default.
• W1502632993 cites W1508255461 @default.
• W1502632993 cites W1513001497 @default.
• W1502632993 cites W1513471900 @default.
• W1502632993 cites W1566727921 @default.
• W1502632993 cites W1568755291 @default.
• W1502632993 cites W1576548686 @default.
• W1502632993 cites W1587964038 @default.
• W1502632993 cites W1591153814 @default.
• W1502632993 cites W1601039912 @default.
• W1502632993 cites W1806267750 @default.
• W1502632993 cites W1901526008 @default.
• W1502632993 cites W1964856587 @default.
• W1502632993 cites W1967922769 @default.
• W1502632993 cites W1970813260 @default.
• W1502632993 cites W1972207851 @default.
• W1502632993 cites W1973709235 @default.
• W1502632993 cites W1982000283 @default.
• W1502632993 cites W1983236845 @default.
• W1502632993 cites W1989289560 @default.
• W1502632993 cites W1990249263 @default.
• W1502632993 cites W1992813613 @default.
• W1502632993 cites W1994861629 @default.
• W1502632993 cites W2013956200 @default.
• W1502632993 cites W2019091317 @default.
• W1502632993 cites W2021294833 @default.
• W1502632993 cites W2021811929 @default.
• W1502632993 cites W2027799294 @default.
• W1502632993 cites W2030021261 @default.
• W1502632993 cites W2033706801 @default.
• W1502632993 cites W2039246411 @default.
• W1502632993 cites W2040738328 @default.
• W1502632993 cites W2042460980 @default.
• W1502632993 cites W2042865941 @default.
• W1502632993 cites W2046658894 @default.
• W1502632993 cites W2046687620 @default.
• W1502632993 cites W2047076303 @default.
• W1502632993 cites W2057402123 @default.
• W1502632993 cites W2058665473 @default.
• W1502632993 cites W2060943762 @default.
• W1502632993 cites W2061445816 @default.
• W1502632993 cites W2062993520 @default.
• W1502632993 cites W2065522032 @default.
• W1502632993 cites W2066505423 @default.
• W1502632993 cites W2068237785 @default.
• W1502632993 cites W2068382277 @default.
• W1502632993 cites W2069380892 @default.
• W1502632993 cites W2070553406 @default.
• W1502632993 cites W2081415676 @default.
• W1502632993 cites W2082231460 @default.
• W1502632993 cites W2090974295 @default.
• W1502632993 cites W2091428206 @default.
• W1502632993 cites W2093229075 @default.
• W1502632993 cites W2093608501 @default.
• W1502632993 cites W2095350647 @default.
• W1502632993 cites W2098582456 @default.
• W1502632993 cites W2101233587 @default.
• W1502632993 cites W2101668065 @default.
• W1502632993 cites W2102607755 @default.
• W1502632993 cites W2103826070 @default.
• W1502632993 cites W2107895127 @default.
• W1502632993 cites W2108579966 @default.
• W1502632993 cites W2119071913 @default.
• W1502632993 cites W2122526508 @default.
• W1502632993 cites W2129690290 @default.
• W1502632993 cites W2136160086 @default.
• W1502632993 cites W2138871581 @default.
• W1502632993 cites W2145443633 @default.
• W1502632993 cites W2145617693 @default.
• W1502632993 cites W2148841660 @default.
• W1502632993 cites W2149955121 @default.
• W1502632993 cites W2151755964 @default.
• W1502632993 cites W2152809882 @default.
• W1502632993 cites W2155986474 @default.
• W1502632993 cites W2156291426 @default.
• W1502632993 cites W2163069612 @default.
• W1502632993 cites W2164159345 @default.
• W1502632993 cites W2168852688 @default.
• W1502632993 cites W4234676427 @default.
• W1502632993 cites W4249614457 @default.
• W1502632993 cites W4254752226 @default.
• W1502632993 cites W2039693891 @default.

• next