Matches in SemOpenAlex for { <https://semopenalex.org/work/W1502654447> ?p ?o ?g. }
- W1502654447 endingPage "218" @default.
- W1502654447 startingPage "185" @default.
- W1502654447 abstract "Hyperkinetic or dyskinetic disorders are characterized by excessive motor activity that interferes with normal motor control mechanism. Levodopa-induced dyskinesias (LID) are mainly associated with several molecular, biochemical, and physiological changes in the basal ganglia (BG). This chapter focuses on LID. The origin of LID in PD is mainly related to the impact on striatal physiology of nigrostriatal dopaminergic depletion and discontinuous levodopa replacement therapy. These combine to induce abnormal expression of dopamine-receptor signaling and neuropeptides, leading to deranged corticostriatal plasticity. LID generally occur in patients with motor fluctuations and can be classified into three main groups: (1) peak-dose choreic or dystonic movements, (2) diphasic dyskinesias, and (3) off -period dystonia. Avoiding pulsatile dopaminergic stimulation results in reduction in the incidence and severity of LID in the general PD population. Treatment of severe LID requires continuous dopaminergic stimulation by means of infusions. DBS of the GPi or the STN is also highly efficacious in the treatment of LID. In patients with very severe and complex LID, GPi-DBS can be a safer indication, even when pallidal surgery is not associated with a significant reduction in daily levodopa intake." @default.
- W1502654447 created "2016-06-24" @default.
- W1502654447 creator A5025874193 @default.
- W1502654447 creator A5026663769 @default.
- W1502654447 creator A5039449388 @default.
- W1502654447 creator A5040404510 @default.
- W1502654447 creator A5041436608 @default.
- W1502654447 creator A5062838955 @default.
- W1502654447 date "2007-01-01" @default.
- W1502654447 modified "2023-10-17" @default.
- W1502654447 title "Levodopa‐induced dyskinesias in Parkinson's disease" @default.
- W1502654447 cites W1241718649 @default.
- W1502654447 cites W138483743 @default.
- W1502654447 cites W14151941 @default.
- W1502654447 cites W1429733086 @default.
- W1502654447 cites W1481697456 @default.
- W1502654447 cites W148624907 @default.
- W1502654447 cites W1508156824 @default.
- W1502654447 cites W1508977838 @default.
- W1502654447 cites W1511761223 @default.
- W1502654447 cites W1520263992 @default.
- W1502654447 cites W1528597597 @default.
- W1502654447 cites W1571781207 @default.
- W1502654447 cites W157595835 @default.
- W1502654447 cites W1593839347 @default.
- W1502654447 cites W175236080 @default.
- W1502654447 cites W1768450208 @default.
- W1502654447 cites W1776005331 @default.
- W1502654447 cites W177724923 @default.
- W1502654447 cites W1778720383 @default.
- W1502654447 cites W182451759 @default.
- W1502654447 cites W1844692487 @default.
- W1502654447 cites W1881911739 @default.
- W1502654447 cites W1893069857 @default.
- W1502654447 cites W1936067042 @default.
- W1502654447 cites W1939235004 @default.
- W1502654447 cites W1963721516 @default.
- W1502654447 cites W1964437271 @default.
- W1502654447 cites W1964962588 @default.
- W1502654447 cites W1964967070 @default.
- W1502654447 cites W1965757588 @default.
- W1502654447 cites W1966092598 @default.
- W1502654447 cites W1966280554 @default.
- W1502654447 cites W1966443363 @default.
- W1502654447 cites W1966567213 @default.
- W1502654447 cites W1968181433 @default.
- W1502654447 cites W1968407662 @default.
- W1502654447 cites W1968943959 @default.
- W1502654447 cites W1969522203 @default.
- W1502654447 cites W1970073512 @default.
- W1502654447 cites W1970534639 @default.
- W1502654447 cites W1970853027 @default.
- W1502654447 cites W1971651517 @default.
- W1502654447 cites W1972908219 @default.
- W1502654447 cites W1973254928 @default.
- W1502654447 cites W1974629156 @default.
- W1502654447 cites W1974629517 @default.
- W1502654447 cites W1975743268 @default.
- W1502654447 cites W1976645888 @default.
- W1502654447 cites W1976816333 @default.
- W1502654447 cites W1976836813 @default.
- W1502654447 cites W1977112433 @default.
- W1502654447 cites W1977484828 @default.
- W1502654447 cites W1978288477 @default.
- W1502654447 cites W1978342336 @default.
- W1502654447 cites W1979460462 @default.
- W1502654447 cites W1979673903 @default.
- W1502654447 cites W1979690917 @default.
- W1502654447 cites W1981170797 @default.
- W1502654447 cites W1981480470 @default.
- W1502654447 cites W1981609060 @default.
- W1502654447 cites W1981821582 @default.
- W1502654447 cites W1982386259 @default.
- W1502654447 cites W1982827121 @default.
- W1502654447 cites W1984340210 @default.
- W1502654447 cites W1986059795 @default.
- W1502654447 cites W1987619728 @default.
- W1502654447 cites W1988330643 @default.
- W1502654447 cites W1988398169 @default.
- W1502654447 cites W1988856687 @default.
- W1502654447 cites W1990080997 @default.
- W1502654447 cites W1990261518 @default.
- W1502654447 cites W1990269363 @default.
- W1502654447 cites W1991532709 @default.
- W1502654447 cites W1991589426 @default.
- W1502654447 cites W1991603311 @default.
- W1502654447 cites W1993109240 @default.
- W1502654447 cites W1993332355 @default.
- W1502654447 cites W1993478531 @default.
- W1502654447 cites W1993697106 @default.
- W1502654447 cites W1994911797 @default.
- W1502654447 cites W1995749717 @default.
- W1502654447 cites W1995906542 @default.
- W1502654447 cites W1996219683 @default.
- W1502654447 cites W1996477091 @default.
- W1502654447 cites W1996727984 @default.
- W1502654447 cites W1997394907 @default.
- W1502654447 cites W1997483903 @default.