FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1502682364> ?p ?o ?g. }

• W1502682364 endingPage "1784" @default.
• W1502682364 startingPage "1773" @default.
• W1502682364 abstract "Herein, chiral selenium nanoparticles (L-SeNPs/D-SeNPs) modified with a dinuclear Ruthenium (II) complex were used to effectively deliver siRNA targeting the MDR1 gene. In this co-delivery system, the luminescent dinuclear Ruthenium (II) complex was developed to act as a gene carrier and anti-tumor drug, while offering luminescent imaging to follow the intracellular trafficking. Interestingly, Ru@L-SeNPs exhibited a stronger protein and pDNA affinity than Ru@D-SeNPs, indicating that chirality may have an effect on pDNA/siRNA binding and biocompatibility. Cisplatin-resistant A549R cells treated with Ru@L-SeNPs-siRNA demonstrated significant downregulation of P-glycoprotein (P-gp) expression, resulting in unprecedented enhanced cytotoxicity through the induction of apoptosis with the involvement of phosphorylation of p53, MAPK and PI3K/Akt signaling pathways. In vivo investigation confirmed that Ru@L-SeNPs-siRNA nanoparticles exhibited high tumor-targeted fluorescence, enhanced anti-tumor efficacy, and decreased systemic toxicity. These results suggest that Ru@L-SeNPs are promising vectors for the delivery of siRNA and for real-time tracking of treatment.In this study, the authors designed bi-functional selenium nanoparticles with specific chirality to deliver siRNA, for targeting tumor MDR1 gene. The underlying ruthenium (II) complex could also offer fluorescence for real-time imaging. This new system has been shown to have enhanced efficacy against drug resistant tumor cells in both in-vitro and in-vivo experiments." @default.
• W1502682364 created "2016-06-24" @default.
• W1502682364 creator A5001723162 @default.
• W1502682364 creator A5004160227 @default.
• W1502682364 creator A5012679128 @default.
• W1502682364 creator A5016275220 @default.
• W1502682364 creator A5044137903 @default.
• W1502682364 creator A5044757842 @default.
• W1502682364 creator A5057261845 @default.
• W1502682364 creator A5069021111 @default.
• W1502682364 creator A5071888774 @default.
• W1502682364 creator A5085352453 @default.
• W1502682364 date "2015-10-01" @default.
• W1502682364 modified "2023-10-16" @default.
• W1502682364 title "Multifunctional selenium nanoparticles: Chiral selectivity of delivering MDR-siRNA for reversal of multidrug resistance and real-time biofluorescence imaging" @default.
• W1502682364 cites W1964483580 @default.
• W1502682364 cites W1965243534 @default.
• W1502682364 cites W1967918611 @default.
• W1502682364 cites W1974632070 @default.
• W1502682364 cites W1975088956 @default.
• W1502682364 cites W1982314943 @default.
• W1502682364 cites W1991998089 @default.
• W1502682364 cites W1993649229 @default.
• W1502682364 cites W1994486848 @default.
• W1502682364 cites W1997527988 @default.
• W1502682364 cites W2010240044 @default.
• W1502682364 cites W2013660362 @default.
• W1502682364 cites W2018652769 @default.
• W1502682364 cites W2023353304 @default.
• W1502682364 cites W2026555523 @default.
• W1502682364 cites W2033346155 @default.
• W1502682364 cites W2041407290 @default.
• W1502682364 cites W2043610941 @default.
• W1502682364 cites W2047110397 @default.
• W1502682364 cites W2049772927 @default.
• W1502682364 cites W2061183788 @default.
• W1502682364 cites W2067053889 @default.
• W1502682364 cites W2069507241 @default.
• W1502682364 cites W2073785896 @default.
• W1502682364 cites W2075015685 @default.
• W1502682364 cites W2082511916 @default.
• W1502682364 cites W2090091283 @default.
• W1502682364 cites W2103943688 @default.
• W1502682364 cites W2104563108 @default.
• W1502682364 cites W2116340094 @default.
• W1502682364 cites W2118144229 @default.
• W1502682364 cites W2129282634 @default.
• W1502682364 cites W2141813746 @default.
• W1502682364 cites W2141839114 @default.
• W1502682364 cites W2141907179 @default.
• W1502682364 cites W2142418153 @default.
• W1502682364 cites W2143939304 @default.
• W1502682364 cites W2145745052 @default.
• W1502682364 cites W2147003856 @default.
• W1502682364 cites W2149984051 @default.
• W1502682364 cites W2156429223 @default.
• W1502682364 cites W2158604280 @default.
• W1502682364 cites W2312266452 @default.
• W1502682364 cites W2314382662 @default.
• W1502682364 cites W2323142798 @default.
• W1502682364 cites W2328075464 @default.
• W1502682364 cites W2330149141 @default.
• W1502682364 cites W4240263597 @default.
• W1502682364 cites W4366716079 @default.
• W1502682364 doi "https://doi.org/10.1016/j.nano.2015.04.011" @default.
• W1502682364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25959925" @default.
• W1502682364 hasPublicationYear "2015" @default.
• W1502682364 type Work @default.
• W1502682364 sameAs 1502682364 @default.
• W1502682364 citedByCount "44" @default.
• W1502682364 countsByYear W15026823642016 @default.
• W1502682364 countsByYear W15026823642017 @default.
• W1502682364 countsByYear W15026823642018 @default.
• W1502682364 countsByYear W15026823642019 @default.
• W1502682364 countsByYear W15026823642020 @default.
• W1502682364 countsByYear W15026823642021 @default.
• W1502682364 countsByYear W15026823642022 @default.
• W1502682364 countsByYear W15026823642023 @default.
• W1502682364 crossrefType "journal-article" @default.
• W1502682364 hasAuthorship W1502682364A5001723162 @default.
• W1502682364 hasAuthorship W1502682364A5004160227 @default.
• W1502682364 hasAuthorship W1502682364A5012679128 @default.
• W1502682364 hasAuthorship W1502682364A5016275220 @default.
• W1502682364 hasAuthorship W1502682364A5044137903 @default.
• W1502682364 hasAuthorship W1502682364A5044757842 @default.
• W1502682364 hasAuthorship W1502682364A5057261845 @default.
• W1502682364 hasAuthorship W1502682364A5069021111 @default.
• W1502682364 hasAuthorship W1502682364A5071888774 @default.
• W1502682364 hasAuthorship W1502682364A5085352453 @default.
• W1502682364 hasConcept C104317684 @default.
• W1502682364 hasConcept C109316439 @default.
• W1502682364 hasConcept C119056186 @default.
• W1502682364 hasConcept C12554922 @default.
• W1502682364 hasConcept C133936738 @default.
• W1502682364 hasConcept C150903083 @default.
• W1502682364 hasConcept C161790260 @default.
• W1502682364 hasConcept C178790620 @default.
• W1502682364 hasConcept C185592680 @default.

• next