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- W1502699107 abstract "The two major epidemiological clues to the pathogenesis of Burkitt lymphoma (BL) are the geographical association with malaria – BL incidence relates to the malaria transmission rate – and early infection by Epstein–Barr virus (EBV). Both agents cause B cell hyperplasia, which is almost certainly an essential component of lymphomagenesis in BL. The critical event in lymphomagenesis is the creation of a MYC translocation, bringing the MYC gene into juxtaposition with immunoglobulin genes and causing its ectopic expression, thereby driving the proliferation of BL cells. It is highly likely that such translocations are mediated by the activation-induced cytidine deaminase (AID) gene, which is responsible for hypervariable region mutations as well as class switching. Stimulation of the Toll-like receptor 9 by malaria-associated agonists induces AID, providing a mechanism whereby malaria could directly influence BL pathogenesis. EBV-containing cells must reach the memory cell compartment in order to survive throughout the life of the individual, which probably requires traversal of the germinal centre. Normally, cells that do not produce high affinity antibodies do not survive this passage, and are induced to undergo apoptosis. EBV, however, prevents this, and in doing so may also enhance the likelihood of survival of rare translocation-containing cells." @default.
- W1502699107 created "2016-06-24" @default.
- W1502699107 creator A5041091901 @default.
- W1502699107 date "2012-01-20" @default.
- W1502699107 modified "2023-10-12" @default.
- W1502699107 title "Epidemiology: clues to the pathogenesis of Burkitt lymphoma" @default.
- W1502699107 cites W1508842698 @default.
- W1502699107 cites W1560434917 @default.
- W1502699107 cites W1570634670 @default.
- W1502699107 cites W1575084332 @default.
- W1502699107 cites W1578954095 @default.
- W1502699107 cites W195731073 @default.
- W1502699107 cites W1961845059 @default.
- W1502699107 cites W1965968822 @default.
- W1502699107 cites W1968948902 @default.
- W1502699107 cites W1970748912 @default.
- W1502699107 cites W1971813536 @default.
- W1502699107 cites W1974673863 @default.
- W1502699107 cites W1979625601 @default.
- W1502699107 cites W1981807499 @default.
- W1502699107 cites W1981951588 @default.
- W1502699107 cites W1986097339 @default.
- W1502699107 cites W1987127024 @default.
- W1502699107 cites W1988046098 @default.
- W1502699107 cites W1992198197 @default.
- W1502699107 cites W1994485651 @default.
- W1502699107 cites W1994636455 @default.
- W1502699107 cites W1995314727 @default.
- W1502699107 cites W2004410061 @default.
- W1502699107 cites W2006691249 @default.
- W1502699107 cites W2007400424 @default.
- W1502699107 cites W2008163304 @default.
- W1502699107 cites W2008297237 @default.
- W1502699107 cites W2014168984 @default.
- W1502699107 cites W2014462867 @default.
- W1502699107 cites W2024510583 @default.
- W1502699107 cites W2026304664 @default.
- W1502699107 cites W2037060985 @default.
- W1502699107 cites W2037788616 @default.
- W1502699107 cites W2040633758 @default.
- W1502699107 cites W2040769229 @default.
- W1502699107 cites W2041371842 @default.
- W1502699107 cites W2041624767 @default.
- W1502699107 cites W2044377496 @default.
- W1502699107 cites W2045309234 @default.
- W1502699107 cites W2045546922 @default.
- W1502699107 cites W2051301388 @default.
- W1502699107 cites W2052210297 @default.
- W1502699107 cites W2059197625 @default.
- W1502699107 cites W2060236569 @default.
- W1502699107 cites W2067608841 @default.
- W1502699107 cites W2068909560 @default.
- W1502699107 cites W2068970201 @default.
- W1502699107 cites W2071775939 @default.
- W1502699107 cites W2077502954 @default.
- W1502699107 cites W2079053367 @default.
- W1502699107 cites W2090026828 @default.
- W1502699107 cites W2090918320 @default.
- W1502699107 cites W2092882033 @default.
- W1502699107 cites W2093913386 @default.
- W1502699107 cites W2094522830 @default.
- W1502699107 cites W2095572685 @default.
- W1502699107 cites W2096203569 @default.
- W1502699107 cites W2103489555 @default.
- W1502699107 cites W2112936683 @default.
- W1502699107 cites W2113473499 @default.
- W1502699107 cites W2118011548 @default.
- W1502699107 cites W2123048981 @default.
- W1502699107 cites W2124286263 @default.
- W1502699107 cites W2127084430 @default.
- W1502699107 cites W2128521779 @default.
- W1502699107 cites W2133131759 @default.
- W1502699107 cites W2151112228 @default.
- W1502699107 cites W2155921882 @default.
- W1502699107 cites W2159064436 @default.
- W1502699107 cites W2160138257 @default.
- W1502699107 cites W2160194666 @default.
- W1502699107 cites W2172230584 @default.
- W1502699107 cites W2268732392 @default.
- W1502699107 cites W2314520604 @default.
- W1502699107 cites W2331156573 @default.
- W1502699107 cites W2349842709 @default.
- W1502699107 cites W2396216814 @default.
- W1502699107 cites W3160257168 @default.
- W1502699107 doi "https://doi.org/10.1111/j.1365-2141.2011.09013.x" @default.
- W1502699107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22260300" @default.
- W1502699107 hasPublicationYear "2012" @default.
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