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- W1502768627 abstract "SummaryParkinsonism is most of the time caused by idiopathic Parkinson’s disease (IPD). Considering the differences in therapeutic response and prognosis, in vivo discrimination between IPD and “parkinsonism-plus” syndromes is important. Recently, ligands have become available for imaging the pre- and postsynaptic dopaminergic system by Single Photon Emission Computed Tomography (SPECT). Visualization of postsynaptic D2 dopamine receptors using 123I-iodobenzamide (123I-IBZM) may contribute to the differential diagnosis between IPD and “parkinsonism-plus” syndromes as IPD is a pure presynaptic disease. Imaging of the presynaptic dopamine transporters using [123I]β-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) may be used as a diagnostic technique. Early disease detection in subjects suspected to be at risk for developing IPD has become possible using [123I]β-CIT or other ligands for the dopamine transporter. Furthermore, with SPECT one is probably able to monitor in an objective way the efficacy of new pharmacological therapies." @default.
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- W1502768627 date "1997-01-01" @default.
- W1502768627 modified "2023-09-26" @default.
- W1502768627 title "IBZM- and CIT-SPECT of the dopaminergic system in parkinsonism" @default.
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- W1502768627 doi "https://doi.org/10.1007/978-3-7091-6842-4_4" @default.
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