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• W1502779454 abstract "The microtubule-associated protein tau is required for microtubule assembly, axonal transport, neurite outgrowth, and stability of microtubules (Binder et al. 1985). Tau selfassembly, aggregation, and accumulation in neurofibrillary tangles (NFTs) are major pathological hallmarks of Alzheimer disease (AD) and other neurodegenerative diseases (Lee et al. 2001, Alonso et al. 2008). Although the importance of tau in AD and other tauopathies is well established (Iqbal et al. 2009, Ballatore et al. 2007, Haroutunian et al. 2007) still unanswered is whether NFTs are the primary neurotoxic factor (Brunden et al. 2008, Marx 2007, Kayed & Jackson 2009). Despite the poor correlation between NFTs and disease progression, and evidence showing, that neuronal loss in AD actually precedes NFTs formation research until recently focused on them and other large meta-stable inclusions composed of aggregated hyperphosphorylated tau protein. Lately, the significance and toxicity of NFTs have been challenged and new aggregated tau entity has emerged as the true pathogenic species in tauopathies and a possible mediator of A┚ toxicity in AD. Tau intermediate aggregate (tau oligomers; aggregates of an intermediate that is between monomers and NFTs in size) can cause neurodegeneration and memory impairment in the absence of A┚. This exciting body of evidence includes results from human brain samples, transgenic mouse and cell-based studies, thus tau oligomers present a new and novel drug target for AD treatment. In this chapter, we summarize the characterization and toxicity of tau oligomers; discuss the evidence supporting their critical role in AD pathogenesis, and the potential and challenges for targeting them by immunotherapy and drug discovery as a novel approach for AD treatment" @default.
• W1502779454 created "2016-06-24" @default.
• W1502779454 creator A5019084646 @default.
• W1502779454 date "2011-09-12" @default.
• W1502779454 modified "2023-09-26" @default.
• W1502779454 title "Tau Oligomers as Potential Drug Target for Alzheimer Disease (AD) Treatment" @default.
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• W1502779454 cites W1494971749 @default.
• W1502779454 cites W1531327859 @default.
• W1502779454 cites W1541326863 @default.
• W1502779454 cites W1567637855 @default.
• W1502779454 cites W1584232106 @default.
• W1502779454 cites W1592702941 @default.
• W1502779454 cites W1593693427 @default.
• W1502779454 cites W1601066682 @default.
• W1502779454 cites W1728812658 @default.
• W1502779454 cites W1960383488 @default.
• W1502779454 cites W1965709917 @default.
• W1502779454 cites W1967187247 @default.
• W1502779454 cites W1968276382 @default.
• W1502779454 cites W1968372370 @default.
• W1502779454 cites W1968673482 @default.
• W1502779454 cites W1976602187 @default.
• W1502779454 cites W1980768099 @default.
• W1502779454 cites W1980825524 @default.
• W1502779454 cites W1981458288 @default.
• W1502779454 cites W1985189653 @default.
• W1502779454 cites W1992503511 @default.
• W1502779454 cites W1994030229 @default.
• W1502779454 cites W1994085255 @default.
• W1502779454 cites W1996694656 @default.
• W1502779454 cites W1996917933 @default.
• W1502779454 cites W1998020365 @default.
• W1502779454 cites W2006051211 @default.
• W1502779454 cites W2011485908 @default.
• W1502779454 cites W2011771839 @default.
• W1502779454 cites W2016758992 @default.
• W1502779454 cites W2018983416 @default.
• W1502779454 cites W2020600076 @default.
• W1502779454 cites W2026101249 @default.
• W1502779454 cites W2031288523 @default.
• W1502779454 cites W2033847972 @default.
• W1502779454 cites W2034286717 @default.
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• W1502779454 cites W2035470211 @default.
• W1502779454 cites W2036755018 @default.
• W1502779454 cites W2038120434 @default.
• W1502779454 cites W2039293162 @default.
• W1502779454 cites W2042485050 @default.
• W1502779454 cites W2043583138 @default.
• W1502779454 cites W2045509178 @default.
• W1502779454 cites W2046624741 @default.
• W1502779454 cites W2048865592 @default.
• W1502779454 cites W2052742260 @default.
• W1502779454 cites W2053116497 @default.
• W1502779454 cites W205316367 @default.
• W1502779454 cites W2054814745 @default.
• W1502779454 cites W2055284645 @default.
• W1502779454 cites W2055371691 @default.
• W1502779454 cites W2056666417 @default.
• W1502779454 cites W2057249855 @default.
• W1502779454 cites W2058570072 @default.
• W1502779454 cites W2060904588 @default.
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• W1502779454 cites W2071982060 @default.
• W1502779454 cites W2082178532 @default.
• W1502779454 cites W2084280842 @default.
• W1502779454 cites W2084453905 @default.
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• W1502779454 cites W2091006863 @default.
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• W1502779454 cites W2092704615 @default.
• W1502779454 cites W2093508682 @default.
• W1502779454 cites W2093852116 @default.
• W1502779454 cites W2100817247 @default.
• W1502779454 cites W2102795669 @default.
• W1502779454 cites W2105704879 @default.
• W1502779454 cites W2105830106 @default.
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• W1502779454 cites W2127004861 @default.
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• W1502779454 cites W2156193029 @default.
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• W1502779454 cites W2167937350 @default.
• W1502779454 cites W75257811 @default.
• W1502779454 doi "https://doi.org/10.5772/16682" @default.
• W1502779454 hasPublicationYear "2011" @default.
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