FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1502912142> ?p ?o ?g. }

• W1502912142 abstract "Two-component systems (TCSs) are the most important sensing mechanisms in bacteria. In Streptomyces, TCSs-mediated responses to environmental stimuli are involved in the regulation of antibiotic production. This study examines the individual role of two histidine kinases (HKs), AbrC1 and AbrC2, which form part of an atypical TCS in Streptomyces coelicolor. qRT-PCR analysis of the expression of both kinases demonstrated that both are expressed at similar levels in NB and NMMP media. Single deletion of abrC1 elicited a significant increase in antibiotic production, while deletion of abrC2 did not have any clear effect. The origin of this phenotype, probably related to the differential phosphorylation ability of the two kinases, was also explored indirectly, analyzing the toxic phenotypes associated with high levels of phosphorylated RR. The higher the AbrC3 regulator phosphorylation rate, the greater the cell toxicity. For the first time, the present work shows in Streptomyces the combined involvement of two different HKs in the response of a regulator to environmental signals. Regarding the possible applications of this research, the fact that an abrC1 deletion mutant overproduces three of the S. coelicolor antibiotics makes this strain an excellent candidate as a host for the heterologous production of secondary metabolites." @default.
• W1502912142 created "2016-06-24" @default.
• W1502912142 creator A5012549844 @default.
• W1502912142 creator A5020613627 @default.
• W1502912142 creator A5029085732 @default.
• W1502912142 creator A5036221193 @default.
• W1502912142 creator A5039869364 @default.
• W1502912142 creator A5066536740 @default.
• W1502912142 creator A5079848082 @default.
• W1502912142 date "2015-05-12" @default.
• W1502912142 modified "2023-10-03" @default.
• W1502912142 title "The two kinases, AbrC1 and AbrC2, of the atypical two-component system AbrC are needed to regulate antibiotic production and differentiation in Streptomyces coelicolor" @default.
• W1502912142 cites W1977198497 @default.
• W1502912142 cites W2012960603 @default.
• W1502912142 cites W2019465627 @default.
• W1502912142 cites W2023950913 @default.
• W1502912142 cites W2052531865 @default.
• W1502912142 cites W2063983512 @default.
• W1502912142 cites W2068140168 @default.
• W1502912142 cites W2068141290 @default.
• W1502912142 cites W2070979982 @default.
• W1502912142 cites W2073126679 @default.
• W1502912142 cites W2094562515 @default.
• W1502912142 cites W2103661938 @default.
• W1502912142 cites W2107093868 @default.
• W1502912142 cites W2107277218 @default.
• W1502912142 cites W2144827388 @default.
• W1502912142 cites W2157934823 @default.
• W1502912142 cites W2168234694 @default.
• W1502912142 cites W2171120339 @default.
• W1502912142 cites W2171164225 @default.
• W1502912142 cites W2192080449 @default.
• W1502912142 doi "https://doi.org/10.3389/fmicb.2015.00450" @default.
• W1502912142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4428217" @default.
• W1502912142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26029189" @default.
• W1502912142 hasPublicationYear "2015" @default.
• W1502912142 type Work @default.
• W1502912142 sameAs 1502912142 @default.
• W1502912142 citedByCount "13" @default.
• W1502912142 countsByYear W15029121422016 @default.
• W1502912142 countsByYear W15029121422017 @default.
• W1502912142 countsByYear W15029121422019 @default.
• W1502912142 countsByYear W15029121422020 @default.
• W1502912142 countsByYear W15029121422021 @default.
• W1502912142 countsByYear W15029121422022 @default.
• W1502912142 countsByYear W15029121422023 @default.
• W1502912142 crossrefType "journal-article" @default.
• W1502912142 hasAuthorship W1502912142A5012549844 @default.
• W1502912142 hasAuthorship W1502912142A5020613627 @default.
• W1502912142 hasAuthorship W1502912142A5029085732 @default.
• W1502912142 hasAuthorship W1502912142A5036221193 @default.
• W1502912142 hasAuthorship W1502912142A5039869364 @default.
• W1502912142 hasAuthorship W1502912142A5066536740 @default.
• W1502912142 hasAuthorship W1502912142A5079848082 @default.
• W1502912142 hasBestOaLocation W15029121421 @default.
• W1502912142 hasConcept C104317684 @default.
• W1502912142 hasConcept C11960822 @default.
• W1502912142 hasConcept C127716648 @default.
• W1502912142 hasConcept C138223613 @default.
• W1502912142 hasConcept C143065580 @default.
• W1502912142 hasConcept C184235292 @default.
• W1502912142 hasConcept C2778905257 @default.
• W1502912142 hasConcept C2779920670 @default.
• W1502912142 hasConcept C2780115692 @default.
• W1502912142 hasConcept C2780681812 @default.
• W1502912142 hasConcept C2781196521 @default.
• W1502912142 hasConcept C523546767 @default.
• W1502912142 hasConcept C54355233 @default.
• W1502912142 hasConcept C55493867 @default.
• W1502912142 hasConcept C6929976 @default.
• W1502912142 hasConcept C86803240 @default.
• W1502912142 hasConcept C89423630 @default.
• W1502912142 hasConcept C95444343 @default.
• W1502912142 hasConceptScore W1502912142C104317684 @default.
• W1502912142 hasConceptScore W1502912142C11960822 @default.
• W1502912142 hasConceptScore W1502912142C127716648 @default.
• W1502912142 hasConceptScore W1502912142C138223613 @default.
• W1502912142 hasConceptScore W1502912142C143065580 @default.
• W1502912142 hasConceptScore W1502912142C184235292 @default.
• W1502912142 hasConceptScore W1502912142C2778905257 @default.
• W1502912142 hasConceptScore W1502912142C2779920670 @default.
• W1502912142 hasConceptScore W1502912142C2780115692 @default.
• W1502912142 hasConceptScore W1502912142C2780681812 @default.
• W1502912142 hasConceptScore W1502912142C2781196521 @default.
• W1502912142 hasConceptScore W1502912142C523546767 @default.
• W1502912142 hasConceptScore W1502912142C54355233 @default.
• W1502912142 hasConceptScore W1502912142C55493867 @default.
• W1502912142 hasConceptScore W1502912142C6929976 @default.
• W1502912142 hasConceptScore W1502912142C86803240 @default.
• W1502912142 hasConceptScore W1502912142C89423630 @default.
• W1502912142 hasConceptScore W1502912142C95444343 @default.
• W1502912142 hasLocation W15029121421 @default.
• W1502912142 hasLocation W15029121422 @default.
• W1502912142 hasLocation W15029121423 @default.
• W1502912142 hasLocation W15029121424 @default.
• W1502912142 hasLocation W15029121425 @default.
• W1502912142 hasLocation W15029121426 @default.
• W1502912142 hasOpenAccess W1502912142 @default.
• W1502912142 hasPrimaryLocation W15029121421 @default.
• W1502912142 hasRelatedWork W1502912142 @default.

• next