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• W1502916179 endingPage "440" @default.
• W1502916179 startingPage "425" @default.
• W1502916179 abstract "Alternative σ-factors of bacteria bind core RNA polymerase to program the specific promoter selectivity of the holoenzyme. Signal-responsive changes in the availability of different σ-factors redistribute the RNA polymerase among the distinct promoter classes in the genome for appropriate adaptive, developmental and survival responses. The σ(54) -factor is structurally and functionally distinct from all other σ-factors. Consequently, binding of σ(54) to RNA polymerase confers unique features on the cognate holoenzyme, which requires activation by an unusual class of mechano-transcriptional activators, whose activities are highly regulated in response to environmental cues. This review summarizes the current understanding of the mechanisms of transcriptional activation by σ(54) -RNA polymerase and highlights the impact of global regulatory factors on transcriptional efficiency from σ(54) -dependent promoters. These global factors include the DNA-bending proteins IHF and CRP, the nucleotide alarmone ppGpp, and the RNA polymerase-targeting protein DksA." @default.
• W1502916179 created "2016-06-24" @default.
• W1502916179 creator A5079517688 @default.
• W1502916179 date "2011-05-01" @default.
• W1502916179 modified "2023-10-12" @default.
• W1502916179 title "Signal sensory systems that impact σ⁵⁴-dependent transcription" @default.
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