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- W1502918845 abstract "HOW TO USE THE SAMPLE SIZE PROGRAM. Identification of Parameters. DESIGN AND ANALYSIS OF RANDOMIZED CLINICAL TRIALS. Formulation of the Therapeutic Question. One-Sided vs. Two-Sided Question. Design of the Clinical Trial. Statistical Considerations. Conduct of the Trial. Analysis and Reporting of the Trial. Critical Elements. Binomial Comparison. Kaplan-Meier Comparison (Large Sample). Logrank Test. DERIVATION OF THE STATISTICAL RESULTS. Derivation of the Large Sample Distribution of the Logrank Statistic. Derivation of the Large Sample Distribution of the Kaplan-Meier Statistic. Difference between Kaplan-Meier Curves. Exponential Survival. Applications of the Logrank Test When Survival is Exponential. Exponential Survival with a Poisson Accrual Process. Extension to the Two-Sample Problem. Exponential Survival with Up-Front Accrual. Proportional Hazard Models and the Exponential Distribution. Consideration in Planning a Trial Under Proportional Hazards: Putting It All Together. Losses to Follow-Up and Sample Size Adjustment. Interpretation of the Program. Multi-Treatment Trials. Stratified Logrank Test. Intuitive Justification Why the Logrank Test and Kaplan-Meier Estimation for Actual Accrual Process Behave in the Limit in the Same Way as the Fixed Binomial Assumption. Alternate Standard Error for the Kaplan-Meier Estimator. Connection between Kaplan-Meier and Binomial. FIGURES. APPENDIX I: A Review of Mathematical Statistics. Expected Value of a Function of a Random Vector. Special Distributions." @default.
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- W1502918845 date "1992-11-30" @default.
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- W1502918845 title "Practical Handbook of Sample Size Guidelines for Clinical Trials" @default.
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