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- W1502956052 abstract "Publisher Summary This chapter discusses the most recent discoveries in the field of vertebrate non-canonical Wnt signaling that point to the existence of a complex non-canonical Wnt signaling network. Wnt proteins constitute a family of secreted glycoproteins that are involved in diverse embryological processes, such as cell differentiation, cell migration, and the establishment of cell polarity These processes are mediated by the activation of different intracellular signaling cascades. The hallmark of the canonical Wnt/ β -catenin pathway is the stabilization of cytoplasmic β -catenin due to the Wnt-mediated inhibition of GSK3- β and the subsequent relocalization of β -catenin to the nucleus. There, β -catenin regulates target gene expression by forming a complex with members of the TCF/LEF family of HMG box transcription factors. Most prominent to this pathway is its extensively studied role in the formation of the dorsal-ventral body axis in vertebrates and its function in carcinogenesis. Specific Wnt proteins trigger intracellular Ca 2+ release, which activates the calciumsensitive protein kinase C (PKC) and Ca 2+ /calmodulin-dependent kinase II (CamKII), the first two calcium-sensitive proteins identified to be regulated by Wnts. The vertebrate Wnt/JNK pathway has been assimilated to represent the planar cell polarity pathway known from Drosophila ." @default.
- W1502956052 created "2016-06-24" @default.
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- W1502956052 date "2005-01-01" @default.
- W1502956052 modified "2023-10-18" @default.
- W1502956052 title "Recent discoveries in vertebrate non‐canonical Wnt signaling: Towards a Wnt signaling network" @default.
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- W1502956052 doi "https://doi.org/10.1016/s1574-3349(05)14005-8" @default.
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