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• W1503022503 endingPage "e363" @default.
• W1503022503 startingPage "e353" @default.
• W1503022503 abstract "Background R-type Ca2+ channels are expressed by myenteric neurons in the guinea pig ileum but the specific function of these channels is unknown. Methods In the present study, we used intracellular electrophysiological techniques to determine the function of R-type Ca2+ channels in myenteric neurons in the acutely isolated longitudinal muscle-myenteric plexus. We used immunohistochemical methods to localize the CaV2.3 subunit of the R-type Ca2+ channel in myenteric neurons. We also studied the effects of the non-selective Ca2+ channel antagonist, CdCl2 (100 μmol L−1), the R-type Ca2+ channel blockers NiCl2 (50 μmol L−1) and SNX-482 (0.1 μmol L−1), and the N-type Ca2+ channel blocker ω-conotoxin GVIA (CTX 0.1 μmol L−1) on action potentials and fast and slow excitatory postsynaptic potentials (fEPSPs and sEPSPs) in S and AH neurons in vitro. Key Results CaV2.3 co-localized with calretinin and calbindin in myenteric neurons. NiCl2 and SNX-482 reduced the duration and amplitude of action potentials in AH but not S neurons. NiCl2 inhibited the afterhyperpolarization in AH neurons. ω-conotoxin GVIA, but not NiCl2, blocked sEPSPs in AH neurons. NiCl2 and SNX-482 inhibited cholinergic, but not cholinergic/purinergic, fEPSPs in S neurons. Conclusions and Inferences These data show that R-type Ca2+ channels contribute to action potentials, but not slow synaptic transmission, in AH neurons. R-type Ca2+ channels contribute to release of acetylcholine as the mediator of fEPSPs in some S neurons. These data indicate that R-type Ca2+ channels may be a target for drugs that selectively modulate activity of AH neurons or could alter fast synaptic excitation in specific pathways in the myenteric plexus." @default.
• W1503022503 created "2016-06-24" @default.
• W1503022503 creator A5035421233 @default.
• W1503022503 creator A5073941282 @default.
• W1503022503 creator A5085256874 @default.
• W1503022503 date "2010-09-06" @default.
• W1503022503 modified "2023-10-03" @default.
• W1503022503 title "R-type Ca2+ channels contribute to fast synaptic excitation and action potentials in subsets of myenteric neurons in the guinea pig intestine" @default.
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• W1503022503 doi "https://doi.org/10.1111/j.1365-2982.2010.01596.x" @default.
• W1503022503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20879993" @default.
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