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- W1503118194 abstract "Introduction: Previous studies have proven that oral administration of donepezil improves prognosis in chronic heart failure (CHF) rats, and most of the cardioprotection has been reproduced by central donepezil infusion. α7-Nicotinic acetylcholine receptors (α7-nAChR) reportedly play an important role in cholinergic anti-inflammation and angiogenesis. The present study aimed to examine whether peripheral blockade of α7-nAChR attenuates beneficial effects of central donepezil infusion in CHF rats. Methods: One week after extensive (50±3%) myocardial infarction (MI), survived rats were implanted with an ECG or a blood pressure transmitter for monitoring chronic hemodynamics. Seven days after surgery, these rats (n=30) were treated with central donepezil infusion (0.1 mg/kg/day) and were randomly assigned to peripheral saline (SDT) or peripheral α7-nAChR blocker, methyllcaconitine (α7DT) infusion groups. After 6-week treatment, the effects of peripheral α7-nAChR blockade were evaluated by hemodynamics, neuro..." @default.
- W1503118194 created "2016-06-24" @default.
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- W1503118194 date "2014-11-25" @default.
- W1503118194 modified "2023-09-25" @default.
- W1503118194 title "Abstract 12116: Peripheral α7-Nicotinic Acetylcholine Receptors Contribute to Cardio-Protective Effects of Central Donepezil Infusion in Chronic Heart Failure Rats" @default.
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