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- W1503148643 abstract "The cellular function of annexin IV was evaluated by correlating tissue expression, cellular localization, and whole-cell electrophysiology. Immunolocalization and biochemical data demonstrate that annexin IV is concentrated along the apical membranes of many epithelia. Introduction of purified exogenous annexin IV into colonic T84 cells through a patch pipette specifically prevented Ca(2+)-dependent Cl- current activation. Affinity-purified antibody against annexin IV applied in the same manner enhanced the activation. Reduction of the endogenous level of annexin IV with a derivatized oligodeoxynucleotide antisense to annexin IV mRNA lowered the threshold for the Ca(2+)-induced current response, mimicking the enhancement of current activation exerted by anti-annexin IV antibody. The inhibitory effect of annexin IV on Ca(2+)-dependent Cl- conductance represents a novel mechanism by which Ca(2+)-binding proteins modulate membrane channel activity." @default.
- W1503148643 created "2016-06-24" @default.
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- W1503148643 date "1994-02-01" @default.
- W1503148643 modified "2023-10-13" @default.
- W1503148643 title "A role for annexin IV in epithelial cell function. Inhibition of calcium-activated chloride conductance." @default.
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- W1503148643 doi "https://doi.org/10.1016/s0021-9258(17)37687-1" @default.
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