FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1503160135> ?p ?o ?g. }

• W1503160135 endingPage "1500" @default.
• W1503160135 startingPage "1492" @default.
• W1503160135 abstract "We propose that protein X provides the connection between damage to Escherichia coli DNA and inhibition of septation and cell division. This connection is needed to guarantee that each new bacterium receives a complete DNA copy. We present several new experiments here which demonstrate that the degree to which septation is inhibited following damage to DNA is correlated with the amount of protein X that is produced. Rifampin selectively blocks protein X production. This drug was shown to allow cells whose DNA had been damaged by nalidixic acid to resume septation. Several mutants formed septa-less filaments and also produced protein X at 42°C; rifampin both inhibited their production of protein X and permitted them to form septa and divide. Essentially complementary results were obtained with a dnaA mutant which at 42°C stopped making DNA, did not produce protein X, and continued to divide; added bleomycin degraded DNA, induced protein X, and inhibited septation. These results, as well as previous observations, are all consistent with the proposal that protein X is produced as a consequence of DNA damage and is an inhibitor of septation. We suggest that septation could require binding of a single-stranded region of DNA to a septum site in the membrane. Protein X could block this binding by combining with the DNA. This control could provide an emergency mechanism in addition to the usually proposed coordination in which completion of DNA synthesis creates a positive effector for a terminal step of septation. Or it could be the sole coordinating mechanism, even under unperturbed growth conditions." @default.
• W1503160135 created "2016-06-24" @default.
• W1503160135 creator A5002769265 @default.
• W1503160135 creator A5029943309 @default.
• W1503160135 date "1978-03-01" @default.
• W1503160135 modified "2023-09-27" @default.
• W1503160135 title "Inhibition of <i>Escherichia coli</i> Division by Protein X" @default.
• W1503160135 cites W1480527855 @default.
• W1503160135 cites W1484743626 @default.
• W1503160135 cites W1489885875 @default.
• W1503160135 cites W1495392635 @default.
• W1503160135 cites W1516444945 @default.
• W1503160135 cites W1545203638 @default.
• W1503160135 cites W1575375592 @default.
• W1503160135 cites W1587485068 @default.
• W1503160135 cites W1600362513 @default.
• W1503160135 cites W1708342446 @default.
• W1503160135 cites W1735673569 @default.
• W1503160135 cites W1877062602 @default.
• W1503160135 cites W1925421966 @default.
• W1503160135 cites W1970396823 @default.
• W1503160135 cites W1989423690 @default.
• W1503160135 cites W1999950740 @default.
• W1503160135 cites W2007192116 @default.
• W1503160135 cites W2016059862 @default.
• W1503160135 cites W2018869205 @default.
• W1503160135 cites W2037626174 @default.
• W1503160135 cites W2044009015 @default.
• W1503160135 cites W2053043749 @default.
• W1503160135 cites W2057058552 @default.
• W1503160135 cites W2063127584 @default.
• W1503160135 cites W2081754116 @default.
• W1503160135 cites W2084121621 @default.
• W1503160135 cites W2117193757 @default.
• W1503160135 cites W2119786560 @default.
• W1503160135 cites W2120813682 @default.
• W1503160135 cites W2166153420 @default.
• W1503160135 doi "https://doi.org/10.1128/jb.133.3.1492-1500.1978" @default.
• W1503160135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/222190" @default.
• W1503160135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/76627" @default.
• W1503160135 hasPublicationYear "1978" @default.
• W1503160135 type Work @default.
• W1503160135 sameAs 1503160135 @default.
• W1503160135 citedByCount "35" @default.
• W1503160135 crossrefType "journal-article" @default.
• W1503160135 hasAuthorship W1503160135A5002769265 @default.
• W1503160135 hasAuthorship W1503160135A5029943309 @default.
• W1503160135 hasBestOaLocation W15031601351 @default.
• W1503160135 hasConcept C104317684 @default.
• W1503160135 hasConcept C107827726 @default.
• W1503160135 hasConcept C143065580 @default.
• W1503160135 hasConcept C1491633281 @default.
• W1503160135 hasConcept C153911025 @default.
• W1503160135 hasConcept C2776237524 @default.
• W1503160135 hasConcept C547475151 @default.
• W1503160135 hasConcept C552990157 @default.
• W1503160135 hasConcept C55468747 @default.
• W1503160135 hasConcept C55493867 @default.
• W1503160135 hasConcept C58337764 @default.
• W1503160135 hasConcept C73573662 @default.
• W1503160135 hasConcept C85813293 @default.
• W1503160135 hasConcept C86803240 @default.
• W1503160135 hasConcept C95444343 @default.
• W1503160135 hasConceptScore W1503160135C104317684 @default.
• W1503160135 hasConceptScore W1503160135C107827726 @default.
• W1503160135 hasConceptScore W1503160135C143065580 @default.
• W1503160135 hasConceptScore W1503160135C1491633281 @default.
• W1503160135 hasConceptScore W1503160135C153911025 @default.
• W1503160135 hasConceptScore W1503160135C2776237524 @default.
• W1503160135 hasConceptScore W1503160135C547475151 @default.
• W1503160135 hasConceptScore W1503160135C552990157 @default.
• W1503160135 hasConceptScore W1503160135C55468747 @default.
• W1503160135 hasConceptScore W1503160135C55493867 @default.
• W1503160135 hasConceptScore W1503160135C58337764 @default.
• W1503160135 hasConceptScore W1503160135C73573662 @default.
• W1503160135 hasConceptScore W1503160135C85813293 @default.
• W1503160135 hasConceptScore W1503160135C86803240 @default.
• W1503160135 hasConceptScore W1503160135C95444343 @default.
• W1503160135 hasIssue "3" @default.
• W1503160135 hasLocation W15031601351 @default.
• W1503160135 hasLocation W15031601352 @default.
• W1503160135 hasLocation W15031601353 @default.
• W1503160135 hasOpenAccess W1503160135 @default.
• W1503160135 hasPrimaryLocation W15031601351 @default.
• W1503160135 hasRelatedWork W1841538792 @default.
• W1503160135 hasRelatedWork W1996038801 @default.
• W1503160135 hasRelatedWork W2006493458 @default.
• W1503160135 hasRelatedWork W2022898490 @default.
• W1503160135 hasRelatedWork W2026535633 @default.
• W1503160135 hasRelatedWork W2039509485 @default.
• W1503160135 hasRelatedWork W2301511862 @default.
• W1503160135 hasRelatedWork W2911540414 @default.
• W1503160135 hasRelatedWork W2974566712 @default.
• W1503160135 hasRelatedWork W3187546345 @default.
• W1503160135 hasVolume "133" @default.
• W1503160135 isParatext "false" @default.
• W1503160135 isRetracted "false" @default.
• W1503160135 magId "1503160135" @default.

• next