Matches in SemOpenAlex for { <https://semopenalex.org/work/W150346066> ?p ?o ?g. }
- W150346066 abstract "Costimulation and coinhibition generated by the B7 family and their receptor CD28 family have key roles in regulating T lymphocyte activation and tolerance. These pathways are very attractive therapeutic targets for human cancers including breast cancer. Gene polymorphisms of B7x (B7-H4/B7S1), PD-1 (CD279), and CTLA-4 (CD152) are associated with increased risk of developing breast cancer although the underlying mechanisms are unclear. In human breast cancer microenvironment, up-regulation of coinhibitory B7/CD28 members B7x, B7-H3 (CD276), and PD-L1 (B7-H1/CD274) on tumor cells as well as PD-1 and PD-L1 on tumor-infiltrating immune cells are emerging as immune evasion pathways. Chemotherapy can affect the expression of these molecules, and therefore may dampen the immune response against breast cancer. Immunotherapy targeting T cell coinhibition as monotherapy or combined with standard therapies are in early stages of clinical development, but hold great promise for treatment of human breast cancer." @default.
- W150346066 created "2016-06-24" @default.
- W150346066 creator A5039297373 @default.
- W150346066 creator A5048939308 @default.
- W150346066 creator A5073670728 @default.
- W150346066 creator A5085875361 @default.
- W150346066 date "2012-10-01" @default.
- W150346066 modified "2023-10-17" @default.
- W150346066 title "T cell coinhibition and immunotherapy in human breast cancer." @default.
- W150346066 cites W1542262758 @default.
- W150346066 cites W1964607427 @default.
- W150346066 cites W1979177232 @default.
- W150346066 cites W1979427594 @default.
- W150346066 cites W1982864957 @default.
- W150346066 cites W1987395624 @default.
- W150346066 cites W1987942065 @default.
- W150346066 cites W1989317719 @default.
- W150346066 cites W1992184534 @default.
- W150346066 cites W1994238092 @default.
- W150346066 cites W1998297552 @default.
- W150346066 cites W1999843687 @default.
- W150346066 cites W2013090484 @default.
- W150346066 cites W2020115881 @default.
- W150346066 cites W2026989399 @default.
- W150346066 cites W2030031549 @default.
- W150346066 cites W2035681097 @default.
- W150346066 cites W2041560123 @default.
- W150346066 cites W2041629170 @default.
- W150346066 cites W2042748313 @default.
- W150346066 cites W2050999762 @default.
- W150346066 cites W2051083170 @default.
- W150346066 cites W2054628179 @default.
- W150346066 cites W2057187391 @default.
- W150346066 cites W2065409049 @default.
- W150346066 cites W2071483270 @default.
- W150346066 cites W2075804595 @default.
- W150346066 cites W2087013294 @default.
- W150346066 cites W2091766131 @default.
- W150346066 cites W2094366129 @default.
- W150346066 cites W2099166599 @default.
- W150346066 cites W2099175643 @default.
- W150346066 cites W2101653483 @default.
- W150346066 cites W2104685923 @default.
- W150346066 cites W2107752337 @default.
- W150346066 cites W2109465910 @default.
- W150346066 cites W2118471749 @default.
- W150346066 cites W2118605519 @default.
- W150346066 cites W2120550461 @default.
- W150346066 cites W2121716986 @default.
- W150346066 cites W2121934915 @default.
- W150346066 cites W2123363005 @default.
- W150346066 cites W2129647998 @default.
- W150346066 cites W2130798549 @default.
- W150346066 cites W2132872147 @default.
- W150346066 cites W2133289699 @default.
- W150346066 cites W2134141915 @default.
- W150346066 cites W2134638467 @default.
- W150346066 cites W2143467222 @default.
- W150346066 cites W2145217698 @default.
- W150346066 cites W2146934263 @default.
- W150346066 cites W2147517180 @default.
- W150346066 cites W2148944915 @default.
- W150346066 cites W2160834915 @default.
- W150346066 cites W2162856391 @default.
- W150346066 cites W2163056200 @default.
- W150346066 cites W2164079212 @default.
- W150346066 cites W2168491140 @default.
- W150346066 cites W2168696771 @default.
- W150346066 cites W2176120669 @default.
- W150346066 cites W2109601337 @default.
- W150346066 cites W2322825061 @default.
- W150346066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4107447" @default.
- W150346066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23114578" @default.
- W150346066 hasPublicationYear "2012" @default.
- W150346066 type Work @default.
- W150346066 sameAs 150346066 @default.
- W150346066 citedByCount "16" @default.
- W150346066 countsByYear W1503460662013 @default.
- W150346066 countsByYear W1503460662014 @default.
- W150346066 countsByYear W1503460662015 @default.
- W150346066 countsByYear W1503460662016 @default.
- W150346066 countsByYear W1503460662017 @default.
- W150346066 countsByYear W1503460662018 @default.
- W150346066 countsByYear W1503460662019 @default.
- W150346066 countsByYear W1503460662021 @default.
- W150346066 countsByYear W1503460662023 @default.
- W150346066 crossrefType "journal-article" @default.
- W150346066 hasAuthorship W150346066A5039297373 @default.
- W150346066 hasAuthorship W150346066A5048939308 @default.
- W150346066 hasAuthorship W150346066A5073670728 @default.
- W150346066 hasAuthorship W150346066A5085875361 @default.
- W150346066 hasConcept C121608353 @default.
- W150346066 hasConcept C126322002 @default.
- W150346066 hasConcept C148125776 @default.
- W150346066 hasConcept C203014093 @default.
- W150346066 hasConcept C2776090121 @default.
- W150346066 hasConcept C2776107976 @default.
- W150346066 hasConcept C2777701055 @default.
- W150346066 hasConcept C2780674031 @default.
- W150346066 hasConcept C502942594 @default.