FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1503541089> ?p ?o ?g. }

• W1503541089 endingPage "1454" @default.
• W1503541089 startingPage "1449" @default.
• W1503541089 abstract "Ataxia-telangiectasia (A-T) is a genetic disease, associated with progressive motor impairment and a lack of functional ATM protein. It has been reported that immunoreactive tyrosine hydroxylase and dopamine transporter are reduced in an Atm-/- mouse model of A-T. These observations led to a hypothesis that A-T is associated with loss of nigrostriatal dopamine and prompted the launch of clinical trials to evaluate a therapeutic utility of the anti-parkinsonian drug, l-DOPA. To test for dopamine depletion more directly, we measured regional levels of monoamines and their metabolites in the Atm-/- mouse brain. We also measured levels of NAD+, a cofactor for dopamine biosynthesis and substrate of the DNA damage surveillance enzyme, poly(ADP-ribose) polymerase (PARP). Constitutive activation of PARP has been posited to cause NAD+ depletion. We observed no reduction in monoamine transmitters and no depletion of NAD+, or other high energy phosphate donors in the adult Atm-/- cerebellum, striatum, or ventral mesencephalon. However, our studies did reveal a progressive sensorimotor impairment in Atm-/- mice that may serve as a relevant proxy for progressive neurological impairment in the human disease. Our results call into question the involvement of dopamine in A-T and the therapeutic strategy of enhancing dopaminergic function with l-DOPA." @default.
• W1503541089 created "2016-06-24" @default.
• W1503541089 creator A5016543815 @default.
• W1503541089 creator A5028263102 @default.
• W1503541089 creator A5047979112 @default.
• W1503541089 creator A5066946932 @default.
• W1503541089 creator A5074353247 @default.
• W1503541089 creator A5083777025 @default.
• W1503541089 creator A5091250799 @default.
• W1503541089 date "2004-02-20" @default.
• W1503541089 modified "2023-10-16" @default.
• W1503541089 title "Progressive sensorimotor impairment is not associated with reduced dopamine and high energy phosphate donors in a model of ataxia-telangiectasia" @default.
• W1503541089 cites W1983577458 @default.
• W1503541089 cites W2004698905 @default.
• W1503541089 cites W2008521151 @default.
• W1503541089 cites W2016313163 @default.
• W1503541089 cites W2018696497 @default.
• W1503541089 cites W2027055290 @default.
• W1503541089 cites W2027969281 @default.
• W1503541089 cites W2033200608 @default.
• W1503541089 cites W2033674626 @default.
• W1503541089 cites W2040051736 @default.
• W1503541089 cites W2044803485 @default.
• W1503541089 cites W2046589688 @default.
• W1503541089 cites W2062833196 @default.
• W1503541089 cites W2063056917 @default.
• W1503541089 cites W2064196546 @default.
• W1503541089 cites W2067758850 @default.
• W1503541089 cites W2071674290 @default.
• W1503541089 cites W2073271223 @default.
• W1503541089 cites W2079269102 @default.
• W1503541089 cites W2084528990 @default.
• W1503541089 cites W2085288390 @default.
• W1503541089 cites W2087367816 @default.
• W1503541089 cites W2088085303 @default.
• W1503541089 cites W2089754219 @default.
• W1503541089 cites W2106087857 @default.
• W1503541089 cites W2159168998 @default.
• W1503541089 cites W2160480808 @default.
• W1503541089 cites W4251745863 @default.
• W1503541089 doi "https://doi.org/10.1046/j.1471-4159.2003.02278.x" @default.
• W1503541089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15009646" @default.
• W1503541089 hasPublicationYear "2004" @default.
• W1503541089 type Work @default.
• W1503541089 sameAs 1503541089 @default.
• W1503541089 citedByCount "19" @default.
• W1503541089 countsByYear W15035410892012 @default.
• W1503541089 countsByYear W15035410892013 @default.
• W1503541089 countsByYear W15035410892014 @default.
• W1503541089 countsByYear W15035410892018 @default.
• W1503541089 crossrefType "journal-article" @default.
• W1503541089 hasAuthorship W1503541089A5016543815 @default.
• W1503541089 hasAuthorship W1503541089A5028263102 @default.
• W1503541089 hasAuthorship W1503541089A5047979112 @default.
• W1503541089 hasAuthorship W1503541089A5066946932 @default.
• W1503541089 hasAuthorship W1503541089A5074353247 @default.
• W1503541089 hasAuthorship W1503541089A5083777025 @default.
• W1503541089 hasAuthorship W1503541089A5091250799 @default.
• W1503541089 hasBestOaLocation W15035410891 @default.
• W1503541089 hasConcept C126322002 @default.
• W1503541089 hasConcept C134018914 @default.
• W1503541089 hasConcept C137183658 @default.
• W1503541089 hasConcept C143425029 @default.
• W1503541089 hasConcept C159167319 @default.
• W1503541089 hasConcept C169760540 @default.
• W1503541089 hasConcept C170493617 @default.
• W1503541089 hasConcept C187714386 @default.
• W1503541089 hasConcept C2775864247 @default.
• W1503541089 hasConcept C2776755682 @default.
• W1503541089 hasConcept C2779486608 @default.
• W1503541089 hasConcept C2780062018 @default.
• W1503541089 hasConcept C513476851 @default.
• W1503541089 hasConcept C552990157 @default.
• W1503541089 hasConcept C55493867 @default.
• W1503541089 hasConcept C71924100 @default.
• W1503541089 hasConcept C86803240 @default.
• W1503541089 hasConceptScore W1503541089C126322002 @default.
• W1503541089 hasConceptScore W1503541089C134018914 @default.
• W1503541089 hasConceptScore W1503541089C137183658 @default.
• W1503541089 hasConceptScore W1503541089C143425029 @default.
• W1503541089 hasConceptScore W1503541089C159167319 @default.
• W1503541089 hasConceptScore W1503541089C169760540 @default.
• W1503541089 hasConceptScore W1503541089C170493617 @default.
• W1503541089 hasConceptScore W1503541089C187714386 @default.
• W1503541089 hasConceptScore W1503541089C2775864247 @default.
• W1503541089 hasConceptScore W1503541089C2776755682 @default.
• W1503541089 hasConceptScore W1503541089C2779486608 @default.
• W1503541089 hasConceptScore W1503541089C2780062018 @default.
• W1503541089 hasConceptScore W1503541089C513476851 @default.
• W1503541089 hasConceptScore W1503541089C552990157 @default.
• W1503541089 hasConceptScore W1503541089C55493867 @default.
• W1503541089 hasConceptScore W1503541089C71924100 @default.
• W1503541089 hasConceptScore W1503541089C86803240 @default.
• W1503541089 hasIssue "6" @default.
• W1503541089 hasLocation W15035410891 @default.
• W1503541089 hasLocation W15035410892 @default.
• W1503541089 hasOpenAccess W1503541089 @default.
• W1503541089 hasPrimaryLocation W15035410891 @default.

• next