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- W1503545908 abstract "Abstract Using in vivo patch‐clamp technique, the slow oscillation of membrane currents was characterized by its synaptic nature, correlation with electroencephalogram (EEG) and responses to different anesthetic agents, in primary somatosensory cortex (SI) neurons in urethane‐anesthetized rats. In more than 90% of the SI neurons, the slow oscillation of the inward currents (0.1–2.5 Hz) with the duration of several hundreds of a millisecond was observed at the holding membrane potential of −70 mV. The reversal potential of the inward currents was approximately 0 mV and was suppressed by application of an α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionate (AMPA) receptor antagonist. In most cases (> 90%) the inward current was synchronized with positive wave of the surface EEG recorded from ipsilateral and even contralateral cortical regions. The frequency as well as duration of the slow oscillation decreased by a volatile anesthetic agent, isoflurane (1.5–5.0%), and excitatory postsynaptic currents (EPSCs) were almost abolished at the highest concentration. Intraperitoneal injection of pentobarbital (25 mg/kg) also decreased the frequency of the slow oscillation without affecting short EPSCs. When γ‐aminobutyric acid A (GABA A ) receptors were activated by local microinjection of muscimol (3 × 10 −3 m , 1–10 µL) into the thalamus, the frequency of the slow oscillation markedly decreased, but was not abolished completely. These findings suggest that the slow oscillation of the inward currents is generated by the summation of glutamatergic EPSCs, and affected by isoflurane and pentobarbital differently. In addition, GABAergic system in the thalamus can affect the frequency, but is not essentially implicated in the genesis of the slow oscillation." @default.
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- W1503545908 date "2007-10-26" @default.
- W1503545908 modified "2023-10-17" @default.
- W1503545908 title "Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons: in vivo patch-clamp analysis" @default.
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- W1503545908 doi "https://doi.org/10.1111/j.1460-9568.2007.05885.x" @default.
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