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- W1503600512 abstract "Background and Objectives Most cell therapy products (CTP) are infused or processed shortly after collection but in some cases this may be delayed for up to 48 h. A number of variables such as temperature and cell concentration are of critical importance for the integrity of CTP during this time. Materials and Methods We conducted a survey of cellular therapy laboratories to ascertain current practices for CTP transportation. Results There were 194 respondents of whom 90% shipped or received CTP – 84% allogeneic, 71% autologous and 62% therapeutic cells. Processing facilities shipped or received the following products – hematopoietic progenitor cells (HPC), Marrow 73%; HPC, Apheresis 90%; HPC, Cord Blood 54% and others 14%. Other CTP included donor lymphocytes, mesenchymal stem cells (MSC), natural killer cells, buffy coat neutrophils and virus‐specific cytotoxic T lymphocytes (CTL). More than 70% of respondents believed that it was acceptable for CTP to be held for up to 2 h without checking the temperature or cell density and a similar proportion agreed that putting products in containers to control parameters such as temperature within this time period was unnecessary. The majority of centres shipped or received between 1 and 10 CTP annually and 66% received products taking more than 2 h to ship. Of these, 82% specified the conditions for temperature in transit whilst 57% monitored temperature in transit and 74% of these used a data logger. The temperature range most commonly specified was 18–24°C. The majority of processing facilities did not request an adjustment to the cell density even for products taking more than 2 h to reach their facility. More than 90% of respondents tested HPC for CD34 + cells, viability and sterility; 40–48% performed colony‐forming unit–granulocyte macrophage (CFU–GM) analysis. Only viability was thought by > 50% of respondents to be impacted by temperature, cell density and other parameters. Conclusion Understanding current practice will help in the design of future studies for CTP storage and transportation." @default.
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- W1503600512 date "2010-07-14" @default.
- W1503600512 modified "2023-10-14" @default.
- W1503600512 title "Transportation of cellular therapy products: report of a survey by the cellular therapies team of the Biomedical Excellence for Safer Transfusion (BEST) collaborative" @default.
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- W1503600512 doi "https://doi.org/10.1111/j.1423-0410.2010.01329.x" @default.
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