Matches in SemOpenAlex for { <https://semopenalex.org/work/W1503605788> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1503605788 endingPage "25" @default.
- W1503605788 startingPage "313" @default.
- W1503605788 abstract "During mammalian fertilization, spermatozoa must undergo capacitation and the acrosome reaction. These processes of sperm function are critically associated with various molecular events and one such process is protein tyrosine phosphorylation (PYP). This event is downstream of increases in intracellular Ca2+ and activities of HCO3- activated adenylate cyclase, cAMP-dependent-protein kinase-A and reactive oxygen species. Though, PYP is known to be mediated by tyrosine kinases and phosphatases, only a few of them have been identified and characterized in spermatozoa. Since most identified tyrosine kinases are soluble proteins from somatic cells, it is believed that distinct mechanisms could exist in spermatozoa for PYP. Such sperm-specific protein tyrosine kinases/ phosphatases still remain to be thoroughly characterized in most species, including hamsters. Nevertheless, a few tyrosine phosphorylated sperm proteins have been identified in hamsters and in other mammals as well. There is very limited information available on our understanding of the molecular and ultrastructural localization, as well as the characteristics of tyrosine phosphorylated proteins. Functionally, how sperm motility is regulated by PYP is also poorly understood. Knowledge of tyrosine phoshorylated proteins and how they regulate sperm function is of immense significance in our understanding of male (in)fertility and clinical management of fertility; especially, in the light of studies that implicate the hypo-tyrosine phosphorylated state of sperm proteins with asthenozoospermic condition in humans. This article provides a comprehensive review on PYP and its regulation by kinases and phosphatases." @default.
- W1503605788 created "2016-06-24" @default.
- W1503605788 creator A5002881301 @default.
- W1503605788 creator A5064070147 @default.
- W1503605788 creator A5076477268 @default.
- W1503605788 date "2007-01-01" @default.
- W1503605788 modified "2023-09-26" @default.
- W1503605788 title "Tyrosine phosphorylated proteins in mammalian spermatozoa: molecular and functional aspects." @default.
- W1503605788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17566281" @default.
- W1503605788 hasPublicationYear "2007" @default.
- W1503605788 type Work @default.
- W1503605788 sameAs 1503605788 @default.
- W1503605788 citedByCount "4" @default.
- W1503605788 countsByYear W15036057882012 @default.
- W1503605788 countsByYear W15036057882019 @default.
- W1503605788 countsByYear W15036057882020 @default.
- W1503605788 crossrefType "journal-article" @default.
- W1503605788 hasAuthorship W1503605788A5002881301 @default.
- W1503605788 hasAuthorship W1503605788A5064070147 @default.
- W1503605788 hasAuthorship W1503605788A5076477268 @default.
- W1503605788 hasConcept C101544691 @default.
- W1503605788 hasConcept C11960822 @default.
- W1503605788 hasConcept C178666793 @default.
- W1503605788 hasConcept C184235292 @default.
- W1503605788 hasConcept C2776165026 @default.
- W1503605788 hasConcept C2777553839 @default.
- W1503605788 hasConcept C2779995066 @default.
- W1503605788 hasConcept C2780301668 @default.
- W1503605788 hasConcept C2781087480 @default.
- W1503605788 hasConcept C42362537 @default.
- W1503605788 hasConcept C54355233 @default.
- W1503605788 hasConcept C55493867 @default.
- W1503605788 hasConcept C58207958 @default.
- W1503605788 hasConcept C62478195 @default.
- W1503605788 hasConcept C85528070 @default.
- W1503605788 hasConcept C86803240 @default.
- W1503605788 hasConcept C87325107 @default.
- W1503605788 hasConcept C95444343 @default.
- W1503605788 hasConcept C97029542 @default.
- W1503605788 hasConceptScore W1503605788C101544691 @default.
- W1503605788 hasConceptScore W1503605788C11960822 @default.
- W1503605788 hasConceptScore W1503605788C178666793 @default.
- W1503605788 hasConceptScore W1503605788C184235292 @default.
- W1503605788 hasConceptScore W1503605788C2776165026 @default.
- W1503605788 hasConceptScore W1503605788C2777553839 @default.
- W1503605788 hasConceptScore W1503605788C2779995066 @default.
- W1503605788 hasConceptScore W1503605788C2780301668 @default.
- W1503605788 hasConceptScore W1503605788C2781087480 @default.
- W1503605788 hasConceptScore W1503605788C42362537 @default.
- W1503605788 hasConceptScore W1503605788C54355233 @default.
- W1503605788 hasConceptScore W1503605788C55493867 @default.
- W1503605788 hasConceptScore W1503605788C58207958 @default.
- W1503605788 hasConceptScore W1503605788C62478195 @default.
- W1503605788 hasConceptScore W1503605788C85528070 @default.
- W1503605788 hasConceptScore W1503605788C86803240 @default.
- W1503605788 hasConceptScore W1503605788C87325107 @default.
- W1503605788 hasConceptScore W1503605788C95444343 @default.
- W1503605788 hasConceptScore W1503605788C97029542 @default.
- W1503605788 hasLocation W15036057881 @default.
- W1503605788 hasOpenAccess W1503605788 @default.
- W1503605788 hasPrimaryLocation W15036057881 @default.
- W1503605788 hasRelatedWork W1143760280 @default.
- W1503605788 hasRelatedWork W1503605788 @default.
- W1503605788 hasRelatedWork W1562710579 @default.
- W1503605788 hasRelatedWork W1870184698 @default.
- W1503605788 hasRelatedWork W2015373368 @default.
- W1503605788 hasRelatedWork W2070192115 @default.
- W1503605788 hasRelatedWork W2094754848 @default.
- W1503605788 hasRelatedWork W2095038256 @default.
- W1503605788 hasRelatedWork W2132487225 @default.
- W1503605788 hasRelatedWork W2142676152 @default.
- W1503605788 hasVolume "63" @default.
- W1503605788 isParatext "false" @default.
- W1503605788 isRetracted "false" @default.
- W1503605788 magId "1503605788" @default.
- W1503605788 workType "article" @default.