FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1503653721> ?p ?o ?g. }

• W1503653721 endingPage "1981" @default.
• W1503653721 startingPage "1968" @default.
• W1503653721 abstract "Accumulating reports suggest that human glioblastoma contains glioma stem-like cells (GSCs) which act as key determinants driving tumor growth, angiogenesis, and contributing to therapeutic resistance. The proliferative signals involved in GSC proliferation and progression remain unclear. Using GSC lines derived from human glioblastoma specimens with different proliferative index and stemness marker expression, we assessed the hypothesis that sphingosine-1-phosphate (S1P) affects the proliferative and stemness properties of GSCs. The results of metabolic studies demonstrated that GSCs rapidly consume newly synthesized ceramide, and export S1P in the extracellular environment, both processes being enhanced in the cells exhibiting high proliferative index and stemness markers. Extracellular S1P levels reached nM concentrations in response to increased extracellular sphingosine. In addition, the presence of EGF and bFGF potentiated the constitutive capacity of GSCs to rapidly secrete newly synthesized S1P, suggesting that cooperation between S1P and these growth factors is of central importance in the maintenance and proliferation of GSCs. We also report for the first time that S1P is able to act as a proliferative and pro-stemness autocrine factor for GSCs, promoting both their cell cycle progression and stemness phenotypic profile. These results suggest for the first time that the GSC population is critically modulated by microenvironmental S1P, this bioactive lipid acting as an autocrine signal to maintain a pro-stemness environment and favoring GSC proliferation, survival and stem properties." @default.
• W1503653721 created "2016-06-24" @default.
• W1503653721 creator A5010798226 @default.
• W1503653721 creator A5014711757 @default.
• W1503653721 creator A5016232876 @default.
• W1503653721 creator A5016947354 @default.
• W1503653721 creator A5029877910 @default.
• W1503653721 creator A5031903259 @default.
• W1503653721 creator A5035637050 @default.
• W1503653721 creator A5056036105 @default.
• W1503653721 creator A5059140593 @default.
• W1503653721 creator A5075486288 @default.
• W1503653721 creator A5076017507 @default.
• W1503653721 creator A5077574557 @default.
• W1503653721 creator A5078056183 @default.
• W1503653721 creator A5087715933 @default.
• W1503653721 creator A5087957483 @default.
• W1503653721 date "2014-07-05" @default.
• W1503653721 modified "2023-10-06" @default.
• W1503653721 title "Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells" @default.
• W1503653721 cites W1492769277 @default.
• W1503653721 cites W1598200894 @default.
• W1503653721 cites W1843461492 @default.
• W1503653721 cites W1965124339 @default.
• W1503653721 cites W1970233014 @default.
• W1503653721 cites W1970241042 @default.
• W1503653721 cites W1972700706 @default.
• W1503653721 cites W1975957651 @default.
• W1503653721 cites W1977811325 @default.
• W1503653721 cites W1979555700 @default.
• W1503653721 cites W1983079076 @default.
• W1503653721 cites W1989638281 @default.
• W1503653721 cites W1991558659 @default.
• W1503653721 cites W1997327044 @default.
• W1503653721 cites W2000973050 @default.
• W1503653721 cites W2001544973 @default.
• W1503653721 cites W2002942874 @default.
• W1503653721 cites W2011543371 @default.
• W1503653721 cites W2011895269 @default.
• W1503653721 cites W2013875639 @default.
• W1503653721 cites W2017883800 @default.
• W1503653721 cites W2018671779 @default.
• W1503653721 cites W2022083485 @default.
• W1503653721 cites W2030326855 @default.
• W1503653721 cites W2031562279 @default.
• W1503653721 cites W2034607874 @default.
• W1503653721 cites W2036182860 @default.
• W1503653721 cites W2037335728 @default.
• W1503653721 cites W2044197183 @default.
• W1503653721 cites W2049719945 @default.
• W1503653721 cites W2050175281 @default.
• W1503653721 cites W2052702367 @default.
• W1503653721 cites W2053310582 @default.
• W1503653721 cites W2053471606 @default.
• W1503653721 cites W2056109576 @default.
• W1503653721 cites W2060551076 @default.
• W1503653721 cites W2063916050 @default.
• W1503653721 cites W2064214863 @default.
• W1503653721 cites W2096287682 @default.
• W1503653721 cites W2101672301 @default.
• W1503653721 cites W2105252420 @default.
• W1503653721 cites W2107591555 @default.
• W1503653721 cites W2108825594 @default.
• W1503653721 cites W2109746323 @default.
• W1503653721 cites W2117767331 @default.
• W1503653721 cites W2119593356 @default.
• W1503653721 cites W2124889811 @default.
• W1503653721 cites W2127032203 @default.
• W1503653721 cites W2129107742 @default.
• W1503653721 cites W2157388625 @default.
• W1503653721 cites W2160382843 @default.
• W1503653721 cites W2162528709 @default.
• W1503653721 cites W2167114006 @default.
• W1503653721 cites W2167444422 @default.
• W1503653721 cites W4211107382 @default.
• W1503653721 doi "https://doi.org/10.1002/glia.22718" @default.
• W1503653721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25042636" @default.
• W1503653721 hasPublicationYear "2014" @default.
• W1503653721 type Work @default.
• W1503653721 sameAs 1503653721 @default.
• W1503653721 citedByCount "38" @default.
• W1503653721 countsByYear W15036537212015 @default.
• W1503653721 countsByYear W15036537212016 @default.
• W1503653721 countsByYear W15036537212017 @default.
• W1503653721 countsByYear W15036537212018 @default.
• W1503653721 countsByYear W15036537212019 @default.
• W1503653721 countsByYear W15036537212020 @default.
• W1503653721 countsByYear W15036537212021 @default.
• W1503653721 countsByYear W15036537212022 @default.
• W1503653721 countsByYear W15036537212023 @default.
• W1503653721 crossrefType "journal-article" @default.
• W1503653721 hasAuthorship W1503653721A5010798226 @default.
• W1503653721 hasAuthorship W1503653721A5014711757 @default.
• W1503653721 hasAuthorship W1503653721A5016232876 @default.
• W1503653721 hasAuthorship W1503653721A5016947354 @default.
• W1503653721 hasAuthorship W1503653721A5029877910 @default.
• W1503653721 hasAuthorship W1503653721A5031903259 @default.
• W1503653721 hasAuthorship W1503653721A5035637050 @default.

• next