FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1503700547> ?p ?o ?g. }

• W1503700547 abstract "The mitogen activated protein kinase (MAPK) cascade is a family of serine-threonine protein kinases controlling a vast array of cellular responses. Among the oldest signaling pathways known, the MAPK cascade is evolutionarily conserved, being found in species ranging from yeast to humans (Widmann et al., 1999). All eukaryotic cells possess multiple MAPK signaling pathways. In mammals, four major subfamilies (termed classical MAPKs) have been identified including extracellular signal-regulated kinase 1/2 (ERK1/2), c-jun Nterminal protein kinases (JNK/SAPK), p38 isoforms (p38 , , , or ), and ERK5 (Dhanasekaran and Johnson, 2007). These multiple parallel MAPK cascades all operate through a three tiered system characterized by consecutive phosphorylation events. Each of the pathways is equipped to respond to a remarkably diverse array of stimuli, including cytokines, growth factors, irradiation, hormones, injury, and stress (Cargnello and Roux, 2011). The binding of stimuli to receptors triggers the initial phosphorylation events. These events transform inactive MAP3K into active MAP3K. Subsequently, active MAP3K phosphorylates, and thereby activates, downstream MAP2K (MEK) proteins. The active MAP2K proteins then phosphorylate MAPK (ERK) molecules. These MAPK proteins then regulate the transcription of a diverse group of genes involved in inflammation, cell survival, cell division, development, metabolism, differentiation, motility, and repair (Cargnello and Roux, 2011)." @default.
• W1503700547 created "2016-06-24" @default.
• W1503700547 creator A5004208068 @default.
• W1503700547 creator A5060745139 @default.
• W1503700547 creator A5067414086 @default.
• W1503700547 date "2012-06-05" @default.
• W1503700547 modified "2023-09-30" @default.
• W1503700547 title "The Role of Tpl2 Protein Kinase in Carcinogenesis and Inflammation" @default.
• W1503700547 cites W1579092429 @default.
• W1503700547 cites W1586373415 @default.
• W1503700547 cites W1809380568 @default.
• W1503700547 cites W1892732379 @default.
• W1503700547 cites W1918903097 @default.
• W1503700547 cites W1964592316 @default.
• W1503700547 cites W1969796663 @default.
• W1503700547 cites W1970617358 @default.
• W1503700547 cites W1972963324 @default.
• W1503700547 cites W1975000516 @default.
• W1503700547 cites W1975628619 @default.
• W1503700547 cites W1987496015 @default.
• W1503700547 cites W1989503423 @default.
• W1503700547 cites W1992735974 @default.
• W1503700547 cites W1997802219 @default.
• W1503700547 cites W1998518433 @default.
• W1503700547 cites W2000476522 @default.
• W1503700547 cites W2001186853 @default.
• W1503700547 cites W2001192666 @default.
• W1503700547 cites W2004207227 @default.
• W1503700547 cites W2014603866 @default.
• W1503700547 cites W2020219604 @default.
• W1503700547 cites W2032261877 @default.
• W1503700547 cites W2032279528 @default.
• W1503700547 cites W2034422847 @default.
• W1503700547 cites W2034658941 @default.
• W1503700547 cites W2038470330 @default.
• W1503700547 cites W2040827479 @default.
• W1503700547 cites W2043287930 @default.
• W1503700547 cites W2058580739 @default.
• W1503700547 cites W2061857121 @default.
• W1503700547 cites W2065833103 @default.
• W1503700547 cites W2071963408 @default.
• W1503700547 cites W2072564827 @default.
• W1503700547 cites W2077537034 @default.
• W1503700547 cites W2079324489 @default.
• W1503700547 cites W2080996150 @default.
• W1503700547 cites W2082712692 @default.
• W1503700547 cites W2084472730 @default.
• W1503700547 cites W2089601189 @default.
• W1503700547 cites W2090362960 @default.
• W1503700547 cites W2091694934 @default.
• W1503700547 cites W2094559285 @default.
• W1503700547 cites W2098719212 @default.
• W1503700547 cites W2105901060 @default.
• W1503700547 cites W2107495112 @default.
• W1503700547 cites W2113709051 @default.
• W1503700547 cites W2113737578 @default.
• W1503700547 cites W2117835779 @default.
• W1503700547 cites W2118424828 @default.
• W1503700547 cites W2128341352 @default.
• W1503700547 cites W2130201289 @default.
• W1503700547 cites W2130277407 @default.
• W1503700547 cites W2139997445 @default.
• W1503700547 cites W2141674733 @default.
• W1503700547 cites W2145722383 @default.
• W1503700547 cites W2148806385 @default.
• W1503700547 cites W2156744692 @default.
• W1503700547 cites W2158720439 @default.
• W1503700547 cites W2163493945 @default.
• W1503700547 cites W2313834443 @default.
• W1503700547 cites W2324000374 @default.
• W1503700547 cites W2406467642 @default.
• W1503700547 cites W2423227803 @default.
• W1503700547 cites W2950532111 @default.
• W1503700547 cites W3146675690 @default.
• W1503700547 doi "https://doi.org/10.5772/38135" @default.
• W1503700547 hasPublicationYear "2012" @default.
• W1503700547 type Work @default.
• W1503700547 sameAs 1503700547 @default.
• W1503700547 citedByCount "2" @default.
• W1503700547 countsByYear W15037005472016 @default.
• W1503700547 countsByYear W15037005472019 @default.
• W1503700547 crossrefType "book-chapter" @default.
• W1503700547 hasAuthorship W1503700547A5004208068 @default.
• W1503700547 hasAuthorship W1503700547A5060745139 @default.
• W1503700547 hasAuthorship W1503700547A5067414086 @default.
• W1503700547 hasBestOaLocation W15037005471 @default.
• W1503700547 hasConcept C121608353 @default.
• W1503700547 hasConcept C124160383 @default.
• W1503700547 hasConcept C126322002 @default.
• W1503700547 hasConcept C184235292 @default.
• W1503700547 hasConcept C2776914184 @default.
• W1503700547 hasConcept C502942594 @default.
• W1503700547 hasConcept C555283112 @default.
• W1503700547 hasConcept C71924100 @default.
• W1503700547 hasConcept C86803240 @default.
• W1503700547 hasConcept C90934575 @default.
• W1503700547 hasConcept C95444343 @default.
• W1503700547 hasConcept C97029542 @default.
• W1503700547 hasConceptScore W1503700547C121608353 @default.
• W1503700547 hasConceptScore W1503700547C124160383 @default.

• next