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• W1503729609 abstract "Osteoarthritis (OA) is a chronic degenerative bone disorder leading to cartilage loss, frequently associated with the aging process. It is widely spread in society and often causes disability. Joint swelling which attends OA is due to osteophyte formation or to synovial fluid accumulation. Pathologically, focal damage of cartilage in load-bearing areas are observed together with the formation of new bone at the joint margins, as well as with changes in subchondral bone, and synovitis. Current diagnosis of OA is based on the clinical history and on the radiographical data which occur late at the disease and are very irreversible. Ideally, we wish to detect osteoarthritis at an early stage by following the changes in expression of particular molecular markers, assuming that these markers are sufficiently sensitive, specific, and quantitative for the disease. OA is no longer considered an exclusively degenerative joint disorder because it is related to changes in the synovial membrane as a result of more or less exerted inflammation (Hedbom & Hauselmann, 2002). Trauma or some mechanical problem might be the primary reason for OA initiation. The initiation and progression of OA is sometimes associated with synovial inflammation and the production of proinflammatory and destructive mediators from the synovium causing the invasion of chondrocytes into the cartilage. In early OA the influx of mononuclear cells is enhanced simultaneously with overexpression of inflammatory molecules compared with late OA (Benito et al., 2005). A fundamental question is which cell populations in OA contribute to and maintain synovial inflammation and cartilage destruction." @default.
• W1503729609 created "2016-06-24" @default.
• W1503729609 creator A5086247761 @default.
• W1503729609 creator A5087697810 @default.
• W1503729609 date "2012-02-22" @default.
• W1503729609 modified "2023-10-02" @default.
• W1503729609 title "How Important are Innate Immunity Cells in Osteoarthritis Pathology" @default.
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