FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1503760388> ?p ?o ?g. }

• W1503760388 endingPage "197" @default.
• W1503760388 startingPage "177" @default.
• W1503760388 abstract "The liver is an essential metabolic organ, and its metabolic function is controlled by insulin and other metabolic hormones. Glucose is converted into pyruvate through glycolysis in the cytoplasm, and pyruvate is subsequently oxidized in the mitochondria to generate ATP through the TCA cycle and oxidative phosphorylation. In the fed state, glycolytic products are used to synthesize fatty acids through de novo lipogenesis. Long-chain fatty acids are incorporated into triacylglycerol, phospholipids, and/or cholesterol esters in hepatocytes. These complex lipids are stored in lipid droplets and membrane structures, or secreted into the circulation as very low-density lipoprotein particles. In the fasted state, the liver secretes glucose through both glycogenolysis and gluconeogenesis. During pronged fasting, hepatic gluconeogenesis is the primary source for endogenous glucose production. Fasting also promotes lipolysis in adipose tissue, resulting in release of nonesterified fatty acids which are converted into ketone bodies in hepatic mitochondria though β-oxidation and ketogenesis. Ketone bodies provide a metabolic fuel for extrahepatic tissues. Liver energy metabolism is tightly regulated by neuronal and hormonal signals. The sympathetic system stimulates, whereas the parasympathetic system suppresses, hepatic gluconeogenesis. Insulin stimulates glycolysis and lipogenesis but suppresses gluconeogenesis, and glucagon counteracts insulin action. Numerous transcription factors and coactivators, including CREB, FOXO1, ChREBP, SREBP, PGC-1α, and CRTC2, control the expression of the enzymes which catalyze key steps of metabolic pathways, thus controlling liver energy metabolism. Aberrant energy metabolism in the liver promotes insulin resistance, diabetes, and nonalcoholic fatty liver diseases. © 2014 American Physiological Society. Compr Physiol 4:177-197, 2014." @default.
• W1503760388 created "2016-06-24" @default.
• W1503760388 creator A5027212562 @default.
• W1503760388 date "2014-01-10" @default.
• W1503760388 modified "2023-10-14" @default.
• W1503760388 title "Energy Metabolism in the Liver" @default.
• W1503760388 cites W1523158326 @default.
• W1503760388 cites W1534360145 @default.
• W1503760388 cites W1574112426 @default.
• W1503760388 cites W1583767403 @default.
• W1503760388 cites W1665938856 @default.
• W1503760388 cites W1748636648 @default.
• W1503760388 cites W1963957834 @default.
• W1503760388 cites W1964443702 @default.
• W1503760388 cites W1964532167 @default.
• W1503760388 cites W1964823824 @default.
• W1503760388 cites W1966157599 @default.
• W1503760388 cites W1966761605 @default.
• W1503760388 cites W1966782228 @default.
• W1503760388 cites W1966922165 @default.
• W1503760388 cites W1969120141 @default.
• W1503760388 cites W1970277428 @default.
• W1503760388 cites W1970896932 @default.
• W1503760388 cites W1972688821 @default.
• W1503760388 cites W1972744939 @default.
• W1503760388 cites W1973916444 @default.
• W1503760388 cites W1975189993 @default.
• W1503760388 cites W1975673963 @default.
• W1503760388 cites W1975962309 @default.
• W1503760388 cites W1979122274 @default.
• W1503760388 cites W1979582511 @default.
• W1503760388 cites W1980321222 @default.
• W1503760388 cites W1982126966 @default.
• W1503760388 cites W1982810858 @default.
• W1503760388 cites W1983082230 @default.
• W1503760388 cites W1983620925 @default.
• W1503760388 cites W1985236262 @default.
• W1503760388 cites W1985478480 @default.
• W1503760388 cites W1985592156 @default.
• W1503760388 cites W1986861420 @default.
• W1503760388 cites W1988012657 @default.
• W1503760388 cites W1988230851 @default.
• W1503760388 cites W1988784323 @default.
• W1503760388 cites W1989177817 @default.
• W1503760388 cites W1990011854 @default.
• W1503760388 cites W1990061996 @default.
• W1503760388 cites W1990607211 @default.
• W1503760388 cites W1990714106 @default.
• W1503760388 cites W1990909446 @default.
• W1503760388 cites W1991401793 @default.
• W1503760388 cites W1993235686 @default.
• W1503760388 cites W1993418845 @default.
• W1503760388 cites W1993987541 @default.
• W1503760388 cites W1994465213 @default.
• W1503760388 cites W1994652351 @default.
• W1503760388 cites W1995856733 @default.
• W1503760388 cites W1995998852 @default.
• W1503760388 cites W1996168740 @default.
• W1503760388 cites W1996821192 @default.
• W1503760388 cites W1998265194 @default.
• W1503760388 cites W1998267856 @default.
• W1503760388 cites W1998585946 @default.
• W1503760388 cites W1999096794 @default.
• W1503760388 cites W2000002411 @default.
• W1503760388 cites W2000047954 @default.
• W1503760388 cites W2000054651 @default.
• W1503760388 cites W2000081372 @default.
• W1503760388 cites W2000955709 @default.
• W1503760388 cites W2001086424 @default.
• W1503760388 cites W2001464177 @default.
• W1503760388 cites W2002789245 @default.
• W1503760388 cites W2003260371 @default.
• W1503760388 cites W2005574862 @default.
• W1503760388 cites W2005911243 @default.
• W1503760388 cites W2007078899 @default.
• W1503760388 cites W2007110763 @default.
• W1503760388 cites W2007486805 @default.
• W1503760388 cites W2007809519 @default.
• W1503760388 cites W2009010832 @default.
• W1503760388 cites W2009046935 @default.
• W1503760388 cites W2009138882 @default.
• W1503760388 cites W2009577529 @default.
• W1503760388 cites W2009781469 @default.
• W1503760388 cites W2010238890 @default.
• W1503760388 cites W2010819467 @default.
• W1503760388 cites W2011497652 @default.
• W1503760388 cites W2011574523 @default.
• W1503760388 cites W2012443360 @default.
• W1503760388 cites W2013655374 @default.
• W1503760388 cites W2014146744 @default.
• W1503760388 cites W2014154105 @default.
• W1503760388 cites W2014631569 @default.
• W1503760388 cites W2014885180 @default.
• W1503760388 cites W2014887370 @default.
• W1503760388 cites W2015711200 @default.
• W1503760388 cites W2016269827 @default.
• W1503760388 cites W2016294119 @default.
• W1503760388 cites W2016366885 @default.

• next