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- W1503854309 abstract "Cancer stem cells (CSCs) play a vital role in cancer progression, maintenance of tumor tissues, and are likely to be the source of tumor recurrence and metastasis. Thus, CSCs are a promising therapeutic target in cancer. The development of novel therapeutic interventions based on the characterization of CSCs is needed to overcome their resistance to conventional anti-cancer therapies. Unfortunately, the separation and purification of the CSCs from human tumor tissues is complicated by a plethora of technical difficulties that prevent the discovery of new anti-CSC drugs. We recently developed a method for preparing induced CSCs by oncogenic reprogramming of non-tumorigenic human mammary epithelial MCF-10A cells via the transduction of defined reprogramming factors. This model is a unique tool not only for analyzing the properties of CSCs but also for screening drugs that selectively target CSCs." @default.
- W1503854309 created "2016-06-24" @default.
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- W1503854309 date "2015-01-29" @default.
- W1503854309 modified "2023-09-26" @default.
- W1503854309 title "Development of an induced cancer stem cell model for drug discovery" @default.
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- W1503854309 doi "https://doi.org/10.14800/ccm.461" @default.
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