FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1503919049> ?p ?o ?g. }

• W1503919049 endingPage "4251" @default.
• W1503919049 startingPage "4246" @default.
• W1503919049 abstract "Varicella-zoster virus (VZV) open reading frame 62 (ORF62) encodes an immediate-early protein that transactivates expression of VZV, herpes simplex virus (HSV), and cellular genes in transient expression assays. VZV ORF62 is homologous to HSV ICP4 and pseudorabies virus immediate-early (IE180) proteins. All three viral proteins have conserved DNA binding domains that recognize similar sites in their corresponding promoters. Here, we show that the transcriptional activation domain of ORF62 is located near the amino terminus of the protein and is not conserved with the activation domain of ICP4. A 161-amino-acid activation domain of ORF62 activates transcription to a level comparable to that of the potent HSV VP16 activation domain; much of the activity is contained in the first 90 amino acids of ORF62. Deletion of the activation domain from full-length ORF62 markedly reduced transactivating activity. These experiments indicate that while VZV ORF62 and HSV ICP4 have conserved amino acid sequences, including their DNA binding domains, the transcriptional activation domains are poorly conserved." @default.
• W1503919049 created "2016-06-24" @default.
• W1503919049 creator A5024634769 @default.
• W1503919049 creator A5066649550 @default.
• W1503919049 creator A5067166920 @default.
• W1503919049 date "1993-07-01" @default.
• W1503919049 modified "2023-09-27" @default.
• W1503919049 title "The transcriptional activation domain of varicella-zoster virus open reading frame 62 protein is not conserved with its herpes simplex virus homolog" @default.
• W1503919049 cites W123433535 @default.
• W1503919049 cites W1488101841 @default.
• W1503919049 cites W1495829907 @default.
• W1503919049 cites W1510529168 @default.
• W1503919049 cites W1567183023 @default.
• W1503919049 cites W1577666052 @default.
• W1503919049 cites W1603246164 @default.
• W1503919049 cites W1671632674 @default.
• W1503919049 cites W1964297270 @default.
• W1503919049 cites W1972677202 @default.
• W1503919049 cites W1975712471 @default.
• W1503919049 cites W1977544393 @default.
• W1503919049 cites W1979647722 @default.
• W1503919049 cites W1982756681 @default.
• W1503919049 cites W1990802697 @default.
• W1503919049 cites W2009310436 @default.
• W1503919049 cites W2029689060 @default.
• W1503919049 cites W2033858354 @default.
• W1503919049 cites W2053700118 @default.
• W1503919049 cites W2057058623 @default.
• W1503919049 cites W2060685508 @default.
• W1503919049 cites W2063466305 @default.
• W1503919049 cites W2065679706 @default.
• W1503919049 cites W2068502447 @default.
• W1503919049 cites W2093032386 @default.
• W1503919049 cites W2093897768 @default.
• W1503919049 cites W2095557476 @default.
• W1503919049 cites W2105346474 @default.
• W1503919049 cites W2106453257 @default.
• W1503919049 cites W2110593918 @default.
• W1503919049 cites W2126202137 @default.
• W1503919049 cites W2141698737 @default.
• W1503919049 doi "https://doi.org/10.1128/jvi.67.7.4246-4251.1993" @default.
• W1503919049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/237794" @default.
• W1503919049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8389926" @default.
• W1503919049 hasPublicationYear "1993" @default.
• W1503919049 type Work @default.
• W1503919049 sameAs 1503919049 @default.
• W1503919049 citedByCount "34" @default.
• W1503919049 countsByYear W15039190492012 @default.
• W1503919049 countsByYear W15039190492014 @default.
• W1503919049 countsByYear W15039190492016 @default.
• W1503919049 crossrefType "journal-article" @default.
• W1503919049 hasAuthorship W1503919049A5024634769 @default.
• W1503919049 hasAuthorship W1503919049A5066649550 @default.
• W1503919049 hasAuthorship W1503919049A5067166920 @default.
• W1503919049 hasBestOaLocation W15039190491 @default.
• W1503919049 hasConcept C104317684 @default.
• W1503919049 hasConcept C138885662 @default.
• W1503919049 hasConcept C153911025 @default.
• W1503919049 hasConcept C159047783 @default.
• W1503919049 hasConcept C167625842 @default.
• W1503919049 hasConcept C179926584 @default.
• W1503919049 hasConcept C2522874641 @default.
• W1503919049 hasConcept C2776159415 @default.
• W1503919049 hasConcept C2781196997 @default.
• W1503919049 hasConcept C33987129 @default.
• W1503919049 hasConcept C41895202 @default.
• W1503919049 hasConcept C47289529 @default.
• W1503919049 hasConcept C515207424 @default.
• W1503919049 hasConcept C54355233 @default.
• W1503919049 hasConcept C77400797 @default.
• W1503919049 hasConcept C86339819 @default.
• W1503919049 hasConcept C86803240 @default.
• W1503919049 hasConcept C94966510 @default.
• W1503919049 hasConceptScore W1503919049C104317684 @default.
• W1503919049 hasConceptScore W1503919049C138885662 @default.
• W1503919049 hasConceptScore W1503919049C153911025 @default.
• W1503919049 hasConceptScore W1503919049C159047783 @default.
• W1503919049 hasConceptScore W1503919049C167625842 @default.
• W1503919049 hasConceptScore W1503919049C179926584 @default.
• W1503919049 hasConceptScore W1503919049C2522874641 @default.
• W1503919049 hasConceptScore W1503919049C2776159415 @default.
• W1503919049 hasConceptScore W1503919049C2781196997 @default.
• W1503919049 hasConceptScore W1503919049C33987129 @default.
• W1503919049 hasConceptScore W1503919049C41895202 @default.
• W1503919049 hasConceptScore W1503919049C47289529 @default.
• W1503919049 hasConceptScore W1503919049C515207424 @default.
• W1503919049 hasConceptScore W1503919049C54355233 @default.
• W1503919049 hasConceptScore W1503919049C77400797 @default.
• W1503919049 hasConceptScore W1503919049C86339819 @default.
• W1503919049 hasConceptScore W1503919049C86803240 @default.
• W1503919049 hasConceptScore W1503919049C94966510 @default.
• W1503919049 hasIssue "7" @default.
• W1503919049 hasLocation W15039190491 @default.
• W1503919049 hasLocation W15039190492 @default.
• W1503919049 hasLocation W15039190493 @default.
• W1503919049 hasLocation W15039190494 @default.
• W1503919049 hasOpenAccess W1503919049 @default.
• W1503919049 hasPrimaryLocation W15039190491 @default.

• next