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• W150403326 abstract "This study aims to investigate the hypoglycaemic and hypocholesterolaemicproperties of Malaysian cocoa (Theobroma cacao) polyphenols extract in-vivo andin-vitro. Cocoa extract (contained 190 - 286 mg total polyphenol per g of extract)was prepared from fermented and roasted (140 C, 20 min) beans by extracting with80% ethanol in the ratio of 1 to 10. The total phenolic content was estimatedaccording to the Folin-Ciocalteu reagent method. The eluted individual polyphenolwas monitored by using a normal-phase HPLC. Monomer is the predominantpolyphenols present in cocoa extract (CE) followed by dimer and tetramer. To studythe effect of CE on plasma glucose levels and lipid profiles in normal and diabeticrats, two different batches of animal (in-vivo) studies were performed. In the firstbatch, rats were given free excess to diet containing CE in the form of powder, whilein the second batch, rats were force-fed with CE suspended in normal saline daily.The CE was given in three dosages (100, 200 and 300 mg per kg body weight) toboth batches for a period of 4 weeks. The result showed that 100 mgkg and 300mgkg CE significantly reduced (p < 0.05) the plasma glucose levels in the diabeticrats of both the first and second batch of studies. In the first batch, supplementationof 100 mgkg and 300 mglkg CE had significantly reduced (p < 0.05) the level oftotal cholesterol in diabetic rats. In addition, 100, 200 and 300 mgkg CE diets hadsignificantly lowered (p < 0.05) the total triglycerides. Interestingly, this study foundthat plasma HDL-cholesterol had increased significantly (p < 0.05) in diabetic ratsfed with 200 mgkg CE, while the LDL-cholesterol had decreased significantly (p <0.05) in group treated with 100 mgkg CE. In the second batch, plasma cholesterol,HDL-cholesterol and LDL-cholesterol levels showed no siginificant difference inboth normal and diabetic rats. Meanwhile, there was a significant decrease (p < 0.05)in plasma triglyceride level in diabetic rats. In another study, rats were pretreatedwith CE to investigate the protective effect of CE against streptozotocin diabetogenicaction. In 200 mglkg CE pretreated rats, there was a 163% increase in plasmaglucose levels, compared with a 226% increase in diabetic control rats. There wereno protective effects on plasma lipid profiles in CE pretreated rats. Results alsoexhibited CE could normalize the body weight loss caused by STZ. BRIN-BD11 celllines (in-vitro) were used to evaluate the effect of CE on insulin secretion. This invitrostudy demonstrated that CE at a concentration of 0.1 mglrnl significantlyincrease (p < 0.05) insulin secretion compared to control. In conclusion, the studyshows that Malaysian cocoa polyphenol extract may possess potentialhypoglycaernic and hypochlosterolaernic properties. Further studies are needed toelucidate the exact mechanism by which polyphenols present in CE can lower theplasma glucose levels and improved lipid profiles in diabetic rats, and stimulateinsulin secretion in BRIN-BDl1 cell lines." @default.
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• W150403326 date "2005-04-01" @default.
• W150403326 modified "2023-09-27" @default.
• W150403326 title "Effects Of Ethanolic Extract Of Cocoa On Blood Glucoseand Lipid Profile In Streptozotocin-Induced Diabetic Rats" @default.
• W150403326 hasPublicationYear "2005" @default.
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