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- W1504034758 abstract "Neurosteroids have siginificant neuroprotection for damaged neurocell and may be developed a kind of potential neuroprotectant for treatment of ischemic stroke. In the study, twelve analogues of 5α-androst-3β,5,6β-triol were synthesized by the multiple steps of reaction from dehydroepiandrosterone (DHEA), and their structures were characterized by IR, NMR, MS. Their neuroprotective activities was tested by evaluating survival cells. The results showed that 3β,5α,6β-trihydroxy sterols (3,4a-4e,5a-5e,11) exhibited certain neuroprotective effect on rat cerebellar granule neurons (CGN) against apoptosis induced by glutamic acid in vitro, and compound 5d and 5e exhibited better neuroprotection with the dose-response relationship." @default.
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- W1504034758 date "2015-10-27" @default.
- W1504034758 modified "2023-09-24" @default.
- W1504034758 title "Synthesis and Neuroprotection of 5α-Androst-3β,5,6β-Triol Derivatives" @default.
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- W1504034758 doi "https://doi.org/10.14800/ttnd.831" @default.
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