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• W1504036545 abstract "Diabetic retinopathy (DR), a major micro-vascular complication of diabetes, has emerged as a leading cause of visual impairment and blindness among working adults in the worldwide. The pathobiology of DR involves multiple molecular pathways and is characterized chronic neurovascular degeneration. Current approaches to prevent or to treat DR are still far from satisfactory. Therefore, it is important to develop new therapeutic strategies for the prevention and treatment to DR. Pigment epithelium-derived factor (PEDF), a 50-kDa secreted glycoprotein, has been described as a multi-functional protein. Some emerging evidences indicate that PEDF are able to target multiple pathways exerting neurotropic, neuroprotective, anti-angiogenic, antivasopermeability, anti-inflammation, anti-thrombogenic and anti-oxidative effects in DR. In this review, we addressed the functions of PEDF in different pathways, which could lead to potential therapeutics on the treatment to DR." @default.
• W1504036545 created "2016-06-24" @default.
• W1504036545 creator A5056137294 @default.
• W1504036545 creator A5056310516 @default.
• W1504036545 creator A5068790715 @default.
• W1504036545 date "2013-01-01" @default.
• W1504036545 modified "2023-10-06" @default.
• W1504036545 title "Potential therapeutic effects of pigment epithelium-derived factor for treatment of diabetic retinopathy." @default.
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• W1504036545 doi "https://doi.org/10.3980/j.issn.2222-3959.2013.02.22" @default.
• W1504036545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3633765" @default.
• W1504036545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23638428" @default.
• W1504036545 hasPublicationYear "2013" @default.
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