Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504090884> ?p ?o ?g. }
- W1504090884 abstract "Publisher Summary Polymers are being extensively investigated to help facilitate nerve regeneration. Entubulization methods involving polymers where a conduit is used to connect the nerve endings has great potential as a repair method for peripheral nerve regeneration. The conduit allows for neurotropic and neurotrophic communication between the nerve stumps and provides physical guidance for the regenerating axons similar to the grafts. The closely fitting tubes facilitate axonal regeneration by inducing rapid development of a highly organized capsule that isolates the repair site and guides and aligns endoneurial components. Entubulization minimizes unregulated axonal growth at the site of injury by providing a distinct environment, and allows for trophic factors emitted from the distal stump to reach the proximal segment, which enhances physiological conditions for nerve regeneration. The spatial cues also induce a change in tissue architecture, with the cabling of cells within the microconduit. The conduits can also be environmentally enhanced with chemical stimulants like laminin and nerve growth factor (NGF), biological cues such as from Schwann cells and astrocytes, the satellite cells of the peripheral and central nervous systems, and lastly, physical guidance cues." @default.
- W1504090884 created "2016-06-24" @default.
- W1504090884 creator A5024041183 @default.
- W1504090884 creator A5051350450 @default.
- W1504090884 date "2004-01-01" @default.
- W1504090884 modified "2023-10-14" @default.
- W1504090884 title "POLYMERIC BIOMATERIALS FOR NERVE REGENERATION" @default.
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