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- W1504154239 abstract "This chapter is focused on noninvasive administration of peptide therapeutics. Beside numerous advantages peptides have over other drug candidates (higher activity per unit mass, increased selectivity and specificity, greater stability at storage, weaker intrinsic immunogenicity, better organ or tumor penetration), some limitations require attention. These limitations are discussed with regard to possible improvement of their bioavailability and biodistribution that are essential for biomedical applications. The study of phosphopeptide P140, a drug candidate for the treatment of systemic lupus erythematosus, is presented in more detail. We describe a new nanoparticle-based formulation of P140 designed for oral administration and some data obtained in a lupus-prone mouse model." @default.
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- W1504154239 date "2013-03-27" @default.
- W1504154239 modified "2023-09-25" @default.
- W1504154239 title "Peptide Nanostructured Conjugates for Therapeutics" @default.
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- W1504154239 doi "https://doi.org/10.1002/9781118592403.ch14" @default.
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