Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504179404> ?p ?o ?g. }
- W1504179404 endingPage "1305" @default.
- W1504179404 startingPage "1293" @default.
- W1504179404 abstract "Dendritic cells (DCs) play a critical role in the immune response to viral infection through the facilitation of cell-intrinsic antiviral activity and the activation of adaptive immunity. HIV-1 infection of DCs triggers an IRF3-dependent innate immune response, which requires the activity of cyclic GAMP synthase (cGAS). We report the results of a targeted RNAi screen utilizing primary human monocyte-derived DCs (MDDCs) to identify immune regulators that directly interface with HIV-1-encoded features to initiate this innate response. Polyglutamine binding protein 1 (PQBP1) emerged as a strong candidate through this analysis. We found that PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with cGAS to initiate an IRF3-dependent innate response. MDDCs derived from Renpenning syndrome patients, who harbor mutations in the PQBP1 locus, possess a severely attenuated innate immune response to HIV-1 challenge, underscoring the role of PQBP1 as a proximal innate sensor of a HIV-1 infection." @default.
- W1504179404 created "2016-06-24" @default.
- W1504179404 creator A5001161369 @default.
- W1504179404 creator A5004889712 @default.
- W1504179404 creator A5005267807 @default.
- W1504179404 creator A5005780833 @default.
- W1504179404 creator A5018042916 @default.
- W1504179404 creator A5019713686 @default.
- W1504179404 creator A5028460941 @default.
- W1504179404 creator A5029578797 @default.
- W1504179404 creator A5033538044 @default.
- W1504179404 creator A5045754024 @default.
- W1504179404 creator A5049699868 @default.
- W1504179404 creator A5064256657 @default.
- W1504179404 creator A5073428265 @default.
- W1504179404 creator A5077090198 @default.
- W1504179404 creator A5090533522 @default.
- W1504179404 date "2015-06-01" @default.
- W1504179404 modified "2023-10-18" @default.
- W1504179404 title "PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1" @default.
- W1504179404 cites W1934619019 @default.
- W1504179404 cites W1964567249 @default.
- W1504179404 cites W1976991589 @default.
- W1504179404 cites W1977855743 @default.
- W1504179404 cites W1980923315 @default.
- W1504179404 cites W1992007798 @default.
- W1504179404 cites W1997069349 @default.
- W1504179404 cites W2016131266 @default.
- W1504179404 cites W2019039109 @default.
- W1504179404 cites W2027798298 @default.
- W1504179404 cites W2027844128 @default.
- W1504179404 cites W2027853473 @default.
- W1504179404 cites W2035702525 @default.
- W1504179404 cites W2038437746 @default.
- W1504179404 cites W2038497568 @default.
- W1504179404 cites W2045628835 @default.
- W1504179404 cites W2051419676 @default.
- W1504179404 cites W2053445583 @default.
- W1504179404 cites W2054932748 @default.
- W1504179404 cites W2058277625 @default.
- W1504179404 cites W2068726804 @default.
- W1504179404 cites W2069554621 @default.
- W1504179404 cites W2076586942 @default.
- W1504179404 cites W2077469182 @default.
- W1504179404 cites W2077915242 @default.
- W1504179404 cites W2078786014 @default.
- W1504179404 cites W2095747840 @default.
- W1504179404 cites W2095968013 @default.
- W1504179404 cites W2099610218 @default.
- W1504179404 cites W2119864130 @default.
- W1504179404 cites W2129798482 @default.
- W1504179404 cites W2134644569 @default.
- W1504179404 cites W2135903629 @default.
- W1504179404 cites W2136329789 @default.
- W1504179404 cites W2154171253 @default.
- W1504179404 cites W2165549831 @default.
- W1504179404 cites W2170241066 @default.
- W1504179404 cites W39050333 @default.
- W1504179404 doi "https://doi.org/10.1016/j.cell.2015.04.050" @default.
- W1504179404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4503237" @default.
- W1504179404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26046437" @default.
- W1504179404 hasPublicationYear "2015" @default.
- W1504179404 type Work @default.
- W1504179404 sameAs 1504179404 @default.
- W1504179404 citedByCount "144" @default.
- W1504179404 countsByYear W15041794042015 @default.
- W1504179404 countsByYear W15041794042016 @default.
- W1504179404 countsByYear W15041794042017 @default.
- W1504179404 countsByYear W15041794042018 @default.
- W1504179404 countsByYear W15041794042019 @default.
- W1504179404 countsByYear W15041794042020 @default.
- W1504179404 countsByYear W15041794042021 @default.
- W1504179404 countsByYear W15041794042022 @default.
- W1504179404 countsByYear W15041794042023 @default.
- W1504179404 crossrefType "journal-article" @default.
- W1504179404 hasAuthorship W1504179404A5001161369 @default.
- W1504179404 hasAuthorship W1504179404A5004889712 @default.
- W1504179404 hasAuthorship W1504179404A5005267807 @default.
- W1504179404 hasAuthorship W1504179404A5005780833 @default.
- W1504179404 hasAuthorship W1504179404A5018042916 @default.
- W1504179404 hasAuthorship W1504179404A5019713686 @default.
- W1504179404 hasAuthorship W1504179404A5028460941 @default.
- W1504179404 hasAuthorship W1504179404A5029578797 @default.
- W1504179404 hasAuthorship W1504179404A5033538044 @default.
- W1504179404 hasAuthorship W1504179404A5045754024 @default.
- W1504179404 hasAuthorship W1504179404A5049699868 @default.
- W1504179404 hasAuthorship W1504179404A5064256657 @default.
- W1504179404 hasAuthorship W1504179404A5073428265 @default.
- W1504179404 hasAuthorship W1504179404A5077090198 @default.
- W1504179404 hasAuthorship W1504179404A5090533522 @default.
- W1504179404 hasBestOaLocation W15041794041 @default.
- W1504179404 hasConcept C136449434 @default.
- W1504179404 hasConcept C137993225 @default.
- W1504179404 hasConcept C159047783 @default.
- W1504179404 hasConcept C193419808 @default.
- W1504179404 hasConcept C203014093 @default.
- W1504179404 hasConcept C2779341262 @default.
- W1504179404 hasConcept C2780209191 @default.