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- W1504283169 abstract "Four years ago we1 presented before this Society a paper which concerned itself with the minimal histologic changes in the cervical biopsy which would justify a diagnosis of carcinoma. Our observations followed those of Schottländer and Kermauner,2 who noted a thin layer of carcinoma extending over the surface, surrounding advanced cervical cancer. They also followed the epochal work of Schiller,3, 4 who first conceived the idea that surface carcinoma could be the beginning of invasive cancer. He described many cases without evidence of invasion in which cellular changes in the surface epithelium were found that were identical to those of invasive cancer. When we undertook our study it appeared to us that there was not sufficient evidence in the literature to justify completely the belief that these intraepithelial changes were precursors of invasive cervical carcinoma. To elucidate this point, we made a comparative histologic study of the biopsy specimens showing malignant changes in the surface epithelium and the ultimate specimens of the cervices removed at hysterectomy. The cervices were cut into several blocks and sections made from different levels in a search for evidence of invasion. In fifteen of the sixteen cervices removed, histologic evidence of invasion was found. Since our publication of 1944, we have continued to collect histologic and clinical evidence concerning this subject and it would seem that we have amassed sufficient data to crystallize our ideas on diagnosis and treatment. This paper is presented before this Society to give our conclusions based on a much wider experience and also with the hope of stimulating discussion concerning this subject." @default.
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- W1504283169 date "1949-01-01" @default.
- W1504283169 modified "2023-09-24" @default.
- W1504283169 title "The present-day status of noninvasive cervical carcinoma" @default.
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- W1504283169 doi "https://doi.org/10.1016/0002-9378(49)90405-6" @default.
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