FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504286609> ?p ?o ?g. }

• W1504286609 endingPage "1329" @default.
• W1504286609 startingPage "1319" @default.
• W1504286609 abstract "The cardiac transient outward current I to is regulated by thyroid hormone (T3). However, it remains unclear whether T3 directly modulates underlying gene transcription and which thyroid receptor (TR) isoform might be responsible for gene transactivation. To clarify this situation, we analysed the role of T3 and its receptors α1 (TRα1) and β1 (TRβ1) in regulation of KCNA4 , KCND2 , KCND3 and KCNIP2 transcription in rat cardiomyocytes. Initial results demonstrated a T3‐mediated increase of I to current density. T3 stimulation enhanced KCND2 and KCND3 expression and decreased KCNA4 transcription, while KCNIP2 remained unaffected. To dissect the role of TRα1 and TRβ1 in T3‐dependent I to modulation, TRα1 and TRβ1 were overexpressed in cardiomyocytes by adenovirus‐mediated gene transfer. TRα1 increased I to , while TRβ1 significantly reduced I to in size, which was associated with TRα1‐mediated increase and TRβ1‐mediated reduction of KCND2 / 3 transcription. To further evaluate a possible direct interaction of TRα1 and TRβ1 with the KCND3 promoter, TR expression vectors were cotransfected with a construct containing 2335 bp of the KCND3 5′‐flanking sequence linked to a luciferase reporter into ventricular myocytes. While the TRα1 aporeceptor enhanced KCND3 transcription, the TRβ1 aporeceptor suppressed KCND3 expression, with both effects exhibiting ligand‐dependent amplification upon T3 stimulation. Deletion of the KCND3 5′‐flanking region localized the suppressible promoter sequence for TRβ1 to within −293 bp and the activating promoter sequence for TRα1 to within −2335 to −1654 bp of the transcription start site. Disruption of putative TR binding sites by mutagenesis abolished the TRα1‐ (G‐1651T) and TRβ1‐ (G‐73T) mediated effects, indicating that TRα1 and TRβ1 response elements map to different regions of the KCND3 promoter. Thus, I to is modulated by diverse T3‐dependent regulation of underlying gene transcription. TRα1 and TRβ1 exhibit distinct effects on KCND3 transactivation with TRα1 enhancing and TRβ1 suppressing KCND3 transcription." @default.
• W1504286609 created "2016-06-24" @default.
• W1504286609 creator A5009967071 @default.
• W1504286609 creator A5014489179 @default.
• W1504286609 creator A5040800792 @default.
• W1504286609 creator A5048543572 @default.
• W1504286609 creator A5073599833 @default.
• W1504286609 creator A5075139311 @default.
• W1504286609 date "2009-03-13" @default.
• W1504286609 modified "2023-10-16" @default.
• W1504286609 title "Divergent regulation of cardiac<i>KCND3</i>potassium channel expression by the thyroid hormone receptors α1 and β1" @default.
• W1504286609 cites W1565592850 @default.
• W1504286609 cites W1977880342 @default.
• W1504286609 cites W1980066114 @default.
• W1504286609 cites W1983588953 @default.
• W1504286609 cites W1987150413 @default.
• W1504286609 cites W1993631912 @default.
• W1504286609 cites W1995486522 @default.
• W1504286609 cites W1995647493 @default.
• W1504286609 cites W2003147376 @default.
• W1504286609 cites W2018750143 @default.
• W1504286609 cites W2022374494 @default.
• W1504286609 cites W2023028256 @default.
• W1504286609 cites W2027342230 @default.
• W1504286609 cites W2028725230 @default.
• W1504286609 cites W2029546557 @default.
• W1504286609 cites W2031240955 @default.
• W1504286609 cites W2038375865 @default.
• W1504286609 cites W2039532381 @default.
• W1504286609 cites W2052820553 @default.
• W1504286609 cites W2067584517 @default.
• W1504286609 cites W2068945957 @default.
• W1504286609 cites W2080457980 @default.
• W1504286609 cites W2082798689 @default.
• W1504286609 cites W2096138350 @default.
• W1504286609 cites W2096950083 @default.
• W1504286609 cites W2100870841 @default.
• W1504286609 cites W2101006158 @default.
• W1504286609 cites W2102038264 @default.
• W1504286609 cites W2107351696 @default.
• W1504286609 cites W2110057127 @default.
• W1504286609 cites W2113625902 @default.
• W1504286609 cites W2120610786 @default.
• W1504286609 cites W2123863731 @default.
• W1504286609 cites W2127271661 @default.
• W1504286609 cites W2127916293 @default.
• W1504286609 cites W2133918950 @default.
• W1504286609 cites W2141742236 @default.
• W1504286609 cites W2142640185 @default.
• W1504286609 cites W2143081191 @default.
• W1504286609 cites W2146189359 @default.
• W1504286609 cites W2149325454 @default.
• W1504286609 cites W2151226843 @default.
• W1504286609 cites W2155032388 @default.
• W1504286609 cites W2158993682 @default.
• W1504286609 cites W2160722013 @default.
• W1504286609 cites W2325705904 @default.
• W1504286609 cites W2417730086 @default.
• W1504286609 cites W4230768631 @default.
• W1504286609 cites W66277886 @default.
• W1504286609 doi "https://doi.org/10.1113/jphysiol.2008.168385" @default.
• W1504286609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2675000" @default.
• W1504286609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19171649" @default.
• W1504286609 hasPublicationYear "2009" @default.
• W1504286609 type Work @default.
• W1504286609 sameAs 1504286609 @default.
• W1504286609 citedByCount "14" @default.
• W1504286609 countsByYear W15042866092012 @default.
• W1504286609 countsByYear W15042866092013 @default.
• W1504286609 countsByYear W15042866092014 @default.
• W1504286609 countsByYear W15042866092016 @default.
• W1504286609 countsByYear W15042866092018 @default.
• W1504286609 countsByYear W15042866092020 @default.
• W1504286609 crossrefType "journal-article" @default.
• W1504286609 hasAuthorship W1504286609A5009967071 @default.
• W1504286609 hasAuthorship W1504286609A5014489179 @default.
• W1504286609 hasAuthorship W1504286609A5040800792 @default.
• W1504286609 hasAuthorship W1504286609A5048543572 @default.
• W1504286609 hasAuthorship W1504286609A5073599833 @default.
• W1504286609 hasAuthorship W1504286609A5075139311 @default.
• W1504286609 hasBestOaLocation W15042866092 @default.
• W1504286609 hasConcept C101762097 @default.
• W1504286609 hasConcept C104317684 @default.
• W1504286609 hasConcept C109115496 @default.
• W1504286609 hasConcept C111335760 @default.
• W1504286609 hasConcept C126322002 @default.
• W1504286609 hasConcept C1292079 @default.
• W1504286609 hasConcept C134018914 @default.
• W1504286609 hasConcept C138885662 @default.
• W1504286609 hasConcept C150194340 @default.
• W1504286609 hasConcept C153911025 @default.
• W1504286609 hasConcept C161733203 @default.
• W1504286609 hasConcept C170493617 @default.
• W1504286609 hasConcept C179926584 @default.
• W1504286609 hasConcept C24998067 @default.
• W1504286609 hasConcept C27153228 @default.
• W1504286609 hasConcept C41895202 @default.
• W1504286609 hasConcept C53345823 @default.

• next