Matches in SemOpenAlex for { <https://semopenalex.org/work/W1504328662> ?p ?o ?g. }
- W1504328662 endingPage "5583" @default.
- W1504328662 startingPage "5576" @default.
- W1504328662 abstract "Murine gammadelta T cell subsets, defined by their Vgamma chain usage, have been shown in various disease models to have distinct functional roles. In this study, we examined the responses of the two main peripheral gammadelta T cell subsets, Vgamma1(+) and Vgamma4(+) cells, during collagen-induced arthritis (CIA), a mouse model that shares many hallmarks with human rheumatoid arthritis. We found that whereas both subsets increased in number, only the Vgamma4(+) cells became activated. Surprisingly, these Vgamma4(+) cells appeared to be Ag selected, based on preferential Vgamma4/Vdelta4 pairing and very limited TCR junctions. Furthermore, in both the draining lymph node and the joints, the vast majority of the Vgamma4/Vdelta4(+) cells produced IL-17, a cytokine that appears to be key in the development of CIA. In fact, the number of IL-17-producing Vgamma4(+) gammadelta T cells in the draining lymph nodes was found to be equivalent to the number of CD4(+)alphabeta(+) Th-17 cells. When mice were depleted of Vgamma4(+) cells, clinical disease scores were significantly reduced and the incidence of disease was lowered. A decrease in total IgG and IgG2a anti-collagen Abs was also seen. These results suggest that Vgamma4/Vdelta4(+) gammadelta T cells exacerbate CIA through their production of IL-17." @default.
- W1504328662 created "2016-06-24" @default.
- W1504328662 creator A5023338227 @default.
- W1504328662 creator A5026634138 @default.
- W1504328662 creator A5046395332 @default.
- W1504328662 creator A5063613068 @default.
- W1504328662 creator A5073213708 @default.
- W1504328662 creator A5079170737 @default.
- W1504328662 date "2007-10-15" @default.
- W1504328662 modified "2023-10-15" @default.
- W1504328662 title "Exacerbation of Collagen-Induced Arthritis by Oligoclonal, IL-17-Producing γδ T Cells" @default.
- W1504328662 cites W126264363 @default.
- W1504328662 cites W1487105384 @default.
- W1504328662 cites W1543653831 @default.
- W1504328662 cites W1553227656 @default.
- W1504328662 cites W1558245619 @default.
- W1504328662 cites W1564175989 @default.
- W1504328662 cites W1654356430 @default.
- W1504328662 cites W1655598064 @default.
- W1504328662 cites W1663604620 @default.
- W1504328662 cites W1841980446 @default.
- W1504328662 cites W1979301746 @default.
- W1504328662 cites W1983464647 @default.
- W1504328662 cites W1988768368 @default.
- W1504328662 cites W1990567364 @default.
- W1504328662 cites W1999287121 @default.
- W1504328662 cites W2006981670 @default.
- W1504328662 cites W2014785961 @default.
- W1504328662 cites W2015865604 @default.
- W1504328662 cites W2021604398 @default.
- W1504328662 cites W2024404066 @default.
- W1504328662 cites W2025939140 @default.
- W1504328662 cites W2034538722 @default.
- W1504328662 cites W2047032886 @default.
- W1504328662 cites W2059508724 @default.
- W1504328662 cites W2064976031 @default.
- W1504328662 cites W2074477433 @default.
- W1504328662 cites W2080359930 @default.
- W1504328662 cites W2082615180 @default.
- W1504328662 cites W2084093106 @default.
- W1504328662 cites W2092690392 @default.
- W1504328662 cites W2100267450 @default.
- W1504328662 cites W2103095633 @default.
- W1504328662 cites W2103438426 @default.
- W1504328662 cites W2115070707 @default.
- W1504328662 cites W2116186506 @default.
- W1504328662 cites W2125438927 @default.
- W1504328662 cites W2127704524 @default.
- W1504328662 cites W2130625679 @default.
- W1504328662 cites W2136357996 @default.
- W1504328662 cites W2144582765 @default.
- W1504328662 cites W2152994600 @default.
- W1504328662 cites W2158854771 @default.
- W1504328662 cites W2167721200 @default.
- W1504328662 cites W2414430764 @default.
- W1504328662 cites W4254690819 @default.
- W1504328662 cites W61961059 @default.
- W1504328662 doi "https://doi.org/10.4049/jimmunol.179.8.5576" @default.
- W1504328662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2768546" @default.
- W1504328662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17911645" @default.
- W1504328662 hasPublicationYear "2007" @default.
- W1504328662 type Work @default.
- W1504328662 sameAs 1504328662 @default.
- W1504328662 citedByCount "277" @default.
- W1504328662 countsByYear W15043286622012 @default.
- W1504328662 countsByYear W15043286622013 @default.
- W1504328662 countsByYear W15043286622014 @default.
- W1504328662 countsByYear W15043286622015 @default.
- W1504328662 countsByYear W15043286622016 @default.
- W1504328662 countsByYear W15043286622017 @default.
- W1504328662 countsByYear W15043286622018 @default.
- W1504328662 countsByYear W15043286622019 @default.
- W1504328662 countsByYear W15043286622020 @default.
- W1504328662 countsByYear W15043286622021 @default.
- W1504328662 countsByYear W15043286622022 @default.
- W1504328662 countsByYear W15043286622023 @default.
- W1504328662 crossrefType "journal-article" @default.
- W1504328662 hasAuthorship W1504328662A5023338227 @default.
- W1504328662 hasAuthorship W1504328662A5026634138 @default.
- W1504328662 hasAuthorship W1504328662A5046395332 @default.
- W1504328662 hasAuthorship W1504328662A5063613068 @default.
- W1504328662 hasAuthorship W1504328662A5073213708 @default.
- W1504328662 hasAuthorship W1504328662A5079170737 @default.
- W1504328662 hasBestOaLocation W15043286621 @default.
- W1504328662 hasConcept C142724271 @default.
- W1504328662 hasConcept C19317047 @default.
- W1504328662 hasConcept C203014093 @default.
- W1504328662 hasConcept C2776090121 @default.
- W1504328662 hasConcept C2777077863 @default.
- W1504328662 hasConcept C2777575956 @default.
- W1504328662 hasConcept C2778690821 @default.
- W1504328662 hasConcept C2779720271 @default.
- W1504328662 hasConcept C2780849966 @default.
- W1504328662 hasConcept C47348012 @default.
- W1504328662 hasConcept C71924100 @default.
- W1504328662 hasConcept C86803240 @default.
- W1504328662 hasConcept C8891405 @default.
- W1504328662 hasConceptScore W1504328662C142724271 @default.